Molecular structure of Picrotoxin, CAS Number: 124-87-8
Picrotoxin (CAS 124-87-8)
See product citations (11)
Alternate Names:
Cocculin
Application:
Picrotoxin is a GABAA receptor antagonist
CAS Number:
124-87-8
Molecular Weight:
602.58
Molecular Formula:
C15H18O7•C15H16O6
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Picrotoxin is a GABAA receptor antagonist, often utilized in neurophysiological research to study the inhibitory neurotransmission mediated by GABA. It binds to the GABAA receptor chloride channel, blocking the flow of chloride ions and thus inhibiting the hyperpolarizing effect of GABA on neurons. This action is useful in experimental applications for probing the dynamics of neuronal excitability and for inducing a controlled state of increased neuronal firing. Research involving picrotoxin also helps in delineating the role of inhibitory synapses in various neural circuits and in the overall regulation of brain activity. Additionally, this compound is instrumental in electrophysiological studies, where it is used to understand the contribution of GABAergic inhibition to phenomena such as oscillatory behavior and synaptic plasticity within neural networks.
Picrotoxin (CAS 124-87-8) References
- Picrotoxin increased acetylcholine release from rat cultured embryonic septal neurons. | Suzuki, T., et al. 2004. Neurosci Lett. 356: 57-60. PMID: 14746901
- Picrotoxin accelerates relaxation of GABAC receptors. | Qian, H., et al. 2005. Mol Pharmacol. 67: 470-9. PMID: 15509715
- Picrotoxin inhibition mechanism of a gamma-aminobutyric acid A receptor investigated by a laser-pulse photolysis technique. | Ramakrishnan, L. and Hess, GP. 2005. Biochemistry. 44: 8523-32. PMID: 15938643
- A picrotoxin-specific conformational change in the glycine receptor M2-M3 loop. | Hawthorne, R. and Lynch, JW. 2005. J Biol Chem. 280: 35836-43. PMID: 16109711
- Neuroendocrine, behavioral and macrophage activity changes induced by picrotoxin effects in mice. | Stankevicius, D., et al. 2008. Neuropharmacology. 54: 300-8. PMID: 18022650
- Stability of picrotoxin during yogurt manufacture and storage. | Jablonski, JE. and Jackson, LS. 2008. J Food Sci. 73: T121-8. PMID: 19019133
- Administration of the GABAA receptor antagonist picrotoxin into rat supramammillary nucleus induces c-Fos in reward-related brain structures. Supramammillary picrotoxin and c-Fos expression. | Shin, R. and Ikemoto, S. 2010. BMC Neurosci. 11: 101. PMID: 20716371
- Picrotoxin but not bicuculline partially abolishes the cardio-inhibitory responses induced by visual stimulation in the crab Neohelice granulata. | Yang, M., et al. 2013. Physiol Behav. 110-111: 198-205. PMID: 23283252
- Picrotoxin dramatically speeds the mammalian circadian clock independent of Cys-loop receptors. | Freeman, GM., et al. 2013. J Neurophysiol. 110: 103-8. PMID: 23576702
- Identification of a possible secondary picrotoxin-binding site on the GABA(A) receptor. | Carpenter, TS., et al. 2013. Chem Res Toxicol. 26: 1444-54. PMID: 24028067
- Effects of picrotoxin treatment on GABAA receptor supramolecular complexes in rat brain. | Ito, Y., et al. 1989. J Neurochem. 52: 1064-70. PMID: 2538560
- Bicuculline and picrotoxin block gamma-aminobutyric acid-gated Cl- conductance by different mechanisms. | Akaike, N., et al. 1985. Experientia. 41: 70-1. PMID: 2578409
- GABAA receptor signalling mechanisms revealed by structural pharmacology. | Masiulis, S., et al. 2019. Nature. 565: 454-459. PMID: 30602790
- Pharmacology of novel GABA receptors found on rod horizontal cells of the white perch retina. | Qian, H. and Dowling, JE. 1994. J Neurosci. 14: 4299-307. PMID: 8027780
- Multiple mechanisms of picrotoxin block of GABA-induced currents in rat hippocampal neurons. | Yoon, KW., et al. 1993. J Physiol. 464: 423-39. PMID: 8229811
Inhibitor of:
GABA Receptor, GABAA θ, GABAA 3, GABAA R rho 1, GABAA Rα2, GABAA Rα3, GABAA Rα4, GABAA Rα5, GABAA Rβ1, GABAA Rβ3, GABAA Rδ, GABAA Rε, GABAA Rγ2, GABAA Rγ3, GABAA Rγ4, GABAA Rπ, GABAA Rρ2, GABAA Rρ3, GABAA Rθ, GABAA Rp, GABAC Rρ1, GABAC Rρ3, GlyR α1 (GLRA1), GlyR α2, GlyR α3, GlyR α4, GlyR β, NP60, Olfr374, Olfr381, Olfr392, Olfr394, Olfr395, Olfr398, Olfr399, Olfr401, Olfr402, Olfr438, Olfr446, Olfr447, Olfr507, Olfr665, Olfr667, Olfr790, Olfr850, Olfr859, Olfr874, Olfr974, Olfr975, Olfr988, SYCE3, V1RF5, and Vmn1r31.Activator of:
1700016H13Rik, Alsin, FBXO2, fidgetin, Gγ 1, GABA T-1, GABAA θ, GABAA 3, GABAA Rβ1, GABAA Rγ1, GABAA Rγ2, GABAA Rρ2, GABAA Rρ3, GABAC Rρ1, GABAC Rρ2, Gephyrin, GluR-δ2, GRIF-1, GRIN3, KCTD4, KCTD7, LRFN3, LRP5L, LRRTM2, Ly-55A, MAGI-2, MBLAC2, Neurensin-2, Neuron navigator 2, NMUR1, Nolz-1, Olfr544, OLIG3, oligophrenin-1, Olr1425, Olr22, Olr24, Olr245, Olr251, ORNT1, ORNT2, PCDHA7, PLEKHJ1, PREP, PRRT1, REEP2, Relaxin 3, SAPAP1, Sg V, SHISA7, SHISA9, SV2A, T2R3, T2R38, TMEM205, TSEN34, TTC17, TULP3, VAX1, VGAT, Vmn1r104, VWC1, and ZNF367.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Picrotoxin, 1 g | sc-202765 | 1 g | $66.00 | |||
Picrotoxin, 5 g | sc-202765A | 5 g | $280.00 | |||
Picrotoxin, 25 g | sc-202765B | 25 g | $1300.00 |