Molecular structure of Lupeol, CAS Number: 545-47-1
Lupeol (CAS 545-47-1)
See product citations (5)
Alternate Names:
Fagarasterol; 20(29)-Lupen-3β-ol; 3β-Hydroxy-20(29)-lupene
Application:
Lupeol is an agent with anti-inflammatory and antioxidant activity
CAS Number:
545-47-1
Purity:
≥98%
Molecular Weight:
426.72
Molecular Formula:
C30H50O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Lupeol is a pentacyclic triterpene that has anti-inflammatory and antioxidant activity. Murine skin studies report that Lupeol inhibits the cutaneous toxicity induced by benzoyl peroxide. Lupeol may act to regulate NF-kappaB and PI3K/Akt pathways, induce Fas-mediated apoptotic death of androgen-sensitive prostate cancer cells, improve the aflatoxin B1-induced peroxidation hepatic damage, and inhibit the Ras signaling pathway. Additionally, Lupeol may act to prevent the effects of DMBA, which induces DNA alkylation damage in mouse skin.
Lupeol (CAS 545-47-1) References
- Lupeol, a triterpene, inhibits early responses of tumor promotion induced by benzoyl peroxide in murine skin. | Saleem, M., et al. 2001. Pharmacol Res. 43: 127-34. PMID: 11243713
- Anti-inflammatory activity of lupeol and lupeol linoleate in rats. | Geetha, T. and Varalakshmi, P. 2001. J Ethnopharmacol. 76: 77-80. PMID: 11378285
- Lupeol modulates NF-kappaB and PI3K/Akt pathways and inhibits skin cancer in CD-1 mice. | Saleem, M., et al. 2004. Oncogene. 23: 5203-14. PMID: 15122342
- Lupeol, a fruit and vegetable based triterpene, induces apoptotic death of human pancreatic adenocarcinoma cells via inhibition of Ras signaling pathway. | Saleem, M., et al. 2005. Carcinogenesis. 26: 1956-64. PMID: 15958516
- A novel dietary triterpene Lupeol induces fas-mediated apoptotic death of androgen-sensitive prostate cancer cells and inhibits tumor growth in a xenograft model. | Saleem, M., et al. 2005. Cancer Res. 65: 11203-13. PMID: 16322271
- Lupeol ameliorates aflatoxin B1-induced peroxidative hepatic damage in rats. | Preetha, SP., et al. 2006. Comp Biochem Physiol C Toxicol Pharmacol. 143: 333-9. PMID: 16730236
- Preventive effects of lupeol on DMBA induced DNA alkylation damage in mouse skin. | Nigam, N., et al. 2007. Food Chem Toxicol. 45: 2331-5. PMID: 17637493
- Lupeol suppresses cisplatin-induced nuclear factor-kappaB activation in head and neck squamous cell carcinoma and inhibits local invasion and nodal metastasis in an orthotopic nude mouse model. | Lee, TK., et al. 2007. Cancer Res. 67: 8800-9. PMID: 17875721
- Lupeol. | Corrêa, RS., et al. 2009. Acta Crystallogr C. 65: o97-9. PMID: 19265231
- Lupeol and its derivatives as anticancer and anti-inflammatory agents: Molecular mechanisms and therapeutic efficacy. | Liu, K., et al. 2021. Pharmacol Res. 164: 105373. PMID: 33316380
- Lupeol protects against cardiac hypertrophy via TLR4-PI3K-Akt-NF-κB pathways. | Li, D., et al. 2022. Acta Pharmacol Sin. 43: 1989-2002. PMID: 34916609
- Molecular pharmacology and therapeutic advances of the pentacyclic triterpene lupeol. | Sohag, AAM., et al. 2022. Phytomedicine. 99: 154012. PMID: 35286936
- Molecular docking analysis of lupeol with different cancer targets. | Gunasekaran, M., et al. 2022. Bioinformation. 18: 134-140. PMID: 36518133
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Lupeol, 10 mg | sc-202699 | 10 mg | $61.00 | |||
Lupeol, 50 mg | sc-202699A | 50 mg | $184.00 | |||
Lupeol, 1 g | sc-202699B | 1 g | $2045.00 |