Honokiol (CAS 35354-74-6)
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Honokiol is a biphyl neolignan present in the cones, bark, and leaves of Magnolia grandifloris that displays anti-angiogenic, anti-tumor and anxiolytic properties. It inhibits phosphorylation of Akt, p44/42 mitogen-activated protein kinase (MAPK), and src. Additionally, honokiol modulates the nuclear factor κ B (NF-κB) activation pathway, an upstream effector of vascular endothelial growth factor (VEGF), cyclooxygenase 2 (COX-2), and MCL1, all significant pro-angiogenic and survival factors. Honokiol is known to display anti-tumor, anti-angiogenic and anxiolytic properties, and has been shown to induce apoptosis and preferentially inhibit human endothelial cell growth over fibroblasts by VEGFR2 autophosphorylation blocking and subsequent rac activation. Honokiol induces caspase-dependent apoptosis in a TRAIL-mediated manner, and potentiates the pro-apoptotic effects of doxorubicin and other etoposides. Honokiol has been shown to promote neurite outgrowth and have neuroprotective effects in rat cortical neurons.
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Honokiol (CAS 35354-74-6) References
- Inhibitors of nitric oxide synthesis and TNF-alpha expression from Magnolia obovata in activated macrophages. | Son, HJ., et al. 2000. Planta Med. 66: 469-71. PMID: 10909270
- Down-modulation of Bcl-XL, release of cytochrome c and sequential activation of caspases during honokiol-induced apoptosis in human squamous lung cancer CH27 cells. | Yang, SE., et al. 2002. Biochem Pharmacol. 63: 1641-51. PMID: 12007567
- Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo. | Bai, X., et al. 2003. J Biol Chem. 278: 35501-7. PMID: 12816951
- Honokiol improves learning and memory impairments induced by scopolamine in mice. | Xian, YF., et al. 2015. Eur J Pharmacol. 760: 88-95. PMID: 25912802
- Honokiol Improves Liver Steatosis in Ovariectomized Mice. | Jeong, YH., et al. 2018. Molecules. 23: PMID: 29342107
- Antidepressant-Like Effect and Mechanism of Action of Honokiol on the Mouse Lipopolysaccharide (LPS) Depression Model. | Zhang, B., et al. 2019. Molecules. 24: PMID: 31141940
- Honokiol improves cognitive impairment in APP/PS1 mice through activating mitophagy and mitochondrial unfolded protein response. | Hou, M., et al. 2022. Chem Biol Interact. 351: 109741. PMID: 34752757
- Honokiol suppresses 2,6-dinitrochlorobenzene-induced atopic dermatitis in mice. | Lee, JH. and Im, DS. 2022. J Ethnopharmacol. 289: 115023. PMID: 35074454
- Mitigation of honokiol on fluoride-induced mitochondrial oxidative stress, mitochondrial dysfunction, and cognitive deficits through activating AMPK/PGC-1α/Sirt3. | Wang, D., et al. 2022. J Hazard Mater. 437: 129381. PMID: 35752048
- Identification of magnolol and honokiol as anxiolytic agents in extracts of saiboku-to, an oriental herbal medicine. | Maruyama, Y., et al. 1998. J Nat Prod. 61: 135-8. PMID: 9461663
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Honokiol, 10 mg | sc-202653 | 10 mg | $118.00 | |||
Honokiol, 25 mg | sc-202653A | 25 mg | $178.00 |