Ecdysone (CAS 3604-87-3)
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Ecdysone, a 6-oxo steroid exhibits hydroxy substitutions at positions 2, 3, 14, 22, and 25. Functioning as a prohormone, it serves as a precursor to the primary insect moulting hormone, 20-hydroxyecdysone. Ecdysone manifests itself as a versatile compound, embodying characteristics of a 2beta-hydroxy steroid, 14alpha-hydroxy steroid, 22-hydroxy steroid, 25-hydroxy steroid, 6-oxo steroid, 3beta-sterol, and ecdysteroid. Derived from a hydride of a 5beta-cholestane, it acts as a vital component in the insect molting process. The prothoracicotropic hormone, an insect neurohormone, stimulates the prothoracic glands to release ecdysone, which rapidly converts into its active metabolite, 20-hydroxyecdysone.
Ecdysone (CAS 3604-87-3) References
- Ecdysone induction of MsrA protects against oxidative stress in Drosophila. | Roesijadi, G., et al. 2007. Biochem Biophys Res Commun. 354: 511-6. PMID: 17239346
- Ecdysone promotes growth of imaginal discs through the regulation of Thor in D. melanogaster. | Herboso, L., et al. 2015. Sci Rep. 5: 12383. PMID: 26198204
- Ecdysone signaling regulates soldier-specific cuticular pigmentation in the termite Zootermopsis nevadensis. | Masuoka, Y. and Maekawa, K. 2016. FEBS Lett. 590: 1694-703. PMID: 27208413
- Ecdysone signaling underlies the pea aphid transgenerational wing polyphenism. | Vellichirammal, NN., et al. 2017. Proc Natl Acad Sci U S A. 114: 1419-1423. PMID: 28115695
- Ecdysone Elicits Chronic Renal Impairment via Mineralocorticoid-Like Pathogenic Activities. | Lu, M., et al. 2018. Cell Physiol Biochem. 49: 1633-1645. PMID: 30227391
- Sexual Dimorphism: Ecdysone Modulates Sex Differences in the Gut. | Millington, JW. and Rideout, EJ. 2020. Curr Biol. 30: R1327-R1330. PMID: 33142105
- Ecdysone Quantification from Whole Body Samples of Drosophila melanogaster Larvae. | Koyama, T. and Mirth, CK. 2021. Bio Protoc. 11: e3915. PMID: 33732802
- Ecdysone signal pathway participates in shell formation in pearl oysters Pinctada fucata martensii. | Xiong, X., et al. 2022. J Steroid Biochem Mol Biol. 217: 106045. PMID: 34915168
- Ecdysone coordinates plastic growth with robust pattern in the developing wing. | Nogueira Alves, A., et al. 2022. Elife. 11: PMID: 35261337
- Essential functions of mosquito ecdysone importers in development and reproduction. | Hun, LV., et al. 2022. Proc Natl Acad Sci U S A. 119: e2202932119. PMID: 35696563
- Functional characterization of putative ecdysone transporters in lepidopteran pests. | Samantsidis, GR., et al. 2022. Insect Biochem Mol Biol. 151: 103830. PMID: 36064128
- Ecdysone acts through cortex glia to regulate sleep in Drosophila. | Li, Y., et al. 2023. Elife. 12: PMID: 36719183
- Diverse functions of the ecdysone receptor (EcR) in the panoistic ovary of the German cockroach. | Rumbo, M., et al. 2023. Insect Biochem Mol Biol. 156: 103935. PMID: 36996928
- [Ecdysone as companion substance of ecdysterone in Polypodium vulgare L]. | Heinrich, G. and Hoffmeister, H. 1967. Experientia. 23: 995. PMID: 6077902
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ecdysone, 1 mg | sc-202595 | 1 mg | $68.00 | |||
Ecdysone, 5 mg | sc-202595A | 5 mg | $226.00 |