Molecular structure of Chlorothiazide, CAS Number: 58-94-6
Chlorothiazide (CAS 58-94-6)
Alternate Names:
6-Chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
Application:
Chlorothiazide is an inhibitor of carbonic anhydrase
CAS Number:
58-94-6
Molecular Weight:
295.72
Molecular Formula:
C7H6N3ClO4S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Chlorothiazide is an inhibitor of carbonic anhydrase and is slightly less potent than acetazolamide (sc-214461). This compound may act to block reabsorption of sodium and chloride ions. Chlorothiazide has been used in a variety of in vitro studies to study its effects on cellular physiology. In cell culture studies, chlorothiazide may act to reduce cell proliferation and induce apoptosis. Its effects diuretics on electrolyte transport, calcium homeostasis, and sodium/potassium pump activity are also studies.
Chlorothiazide (CAS 58-94-6) References
- Studies on the mechanism of diuretic action of chlorothiazide. | PITTS, RF., et al. 1958. J Pharmacol Exp Ther. 123: 89-97. PMID: 13550061
- The mechanism of action of chlorothiazide. | BEYER, KH. 1958. Ann N Y Acad Sci. 71: 363-79. PMID: 13583792
- Mechanism of action of chlorothiazide. | BEYER, KH. 1959. Ther Umsch. 16: 2-9. PMID: 13635627
- Metolazone Versus Intravenous Chlorothiazide for Decompensated Heart Failure Sequential Nephron Blockade: A Retrospective Cohort Study. | Cisowska, T., et al. 2022. J Card Fail. 28: 1367-1371. PMID: 35688407
- Efficacy of pharmacologic therapies in patients with acute heart failure: A network meta-analysis. | Dai, H., et al. 2022. Front Pharmacol. 13: 677589. PMID: 36210851
- Effectiveness of thiazide and thiazide-like diuretics in advanced chronic kidney disease: a systematic review and meta-analysis. | Teles, F., et al. 2023. Ren Fail. 45: 2163903. PMID: 36637019
- Phosphomannomutase 2 (PMM2) variants leading to hyperinsulinism-polycystic kidney disease are associated with early-onset inflammatory bowel disease and gastric antral foveolar hyperplasia. | Kiparissi, F., et al. 2023. Hum Genet. 142: 697-704. PMID: 36773065
- Effect of Antihypertensive Drug (Chlorothiazide) on Fibrillation of Lysozyme: A Combined Spectroscopy, Microscopy, and Computational Study. | Altwaijry, N., et al. 2023. Int J Mol Sci. 24: PMID: 36834523
- Tissue plasminogen activator for axillary Impella 5.0 with heparin-induced thrombocytopenia as a treatment of choice for acute Impella thrombosis: a case report. | Merino, E. and Abdelfattah, OM. 2023. Eur Heart J Case Rep. 7: ytad231. PMID: 37187969
- A case report of percutaneous MitraClip implantation in an adult with a double-outlet right ventricle. | Kumar, P., et al. 2023. Eur Heart J Case Rep. 7: ytad247. PMID: 37288347
- Case Report: Congenital tuberculosis in a premature infant requiring extracorporeal membrane oxygenation. | Quach, HK., et al. 2023. J Extra Corpor Technol. 55: 86-90. PMID: 37378441
- Hyperinsulinemic Hypoglycemia and Growth Hormone Deficiency Secondary to 20p11 Deletion. | Wee, E., et al. 2023. Case Rep Endocrinol. 2023: 8658540. PMID: 37404330
Inhibitor of:
αENaC, Carbonic Anhydrases, Enzyme, NPT1, Sall3, SLC17A (solute carrier family 17), and SLC17A2.Activator of:
NCCT, SLC41A3, SLC4A4, and WNK3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Chlorothiazide, 1 g | sc-202536 | 1 g | $39.00 | |||
Chlorothiazide, 5 g | sc-202536A | 5 g | $107.00 | |||
Chlorothiazide, 10 g | sc-202536B | 10 g | $175.00 |