Molecular structure of Carbamazepine, CAS Number: 298-46-4
Carbamazepine (CAS 298-46-4)
See product citations (5)
Alternate Names:
5H-Dibenz[b,f]azepine-5-carboxamide
Application:
Carbamazepine is a sodium channel protein inhibitor
CAS Number:
298-46-4
Purity:
≥98%
Molecular Weight:
236.27
Molecular Formula:
C15H12N2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Carbamazepine is a sodium channel protein inhibitor. Carbamazepine is a compound consisting of a planar ring and is of particular interest in studying sodium channel interactions and cytochrome P450 (CYP). Carbamazepine has been used in the study of sodium channels in neuronal cells. This compound is reported to bind within the inner pore of the sodium channel via affinity binding with the IV-S6 domain. Additionally, Carbamazepine is reported to be a mechanism-based inhibitor of CYP1A2 as this compound contains a planar ring reported to fit within the planar active site of CYP1A2. This compound is also noted to be an in vitro inducer of CYP3A4, the main human metabolizing enzyme present in the liver and intestine.
Carbamazepine (CAS 298-46-4) References
- Determination of carbamazepine and its metabolite carbamazepine-10,11-epoxide in serum with gas-chromatography mass spectrometry. | Minkova, G. and Getova, D. 2001. Methods Find Exp Clin Pharmacol. 23: 481-5. PMID: 11876020
- Interaction of carbamazepine and promethazine in rabbits. | Rukhadze, MD., et al. 2003. Biomed Chromatogr. 17: 62-9. PMID: 12583009
- General framework for the prediction of oral drug interactions caused by CYP3A4 induction from in vivo information. | Ohno, Y., et al. 2008. Clin Pharmacokinet. 47: 669-80. PMID: 18783297
- The role of sodium channels in the mechanism of action of antidepressants and mood stabilizers. | Bourin, M., et al. 2009. Curr Drug Targets. 10: 1052-60. PMID: 19702557
- Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. | Wang, B. and Zhou, SF. 2009. Curr Med Chem. 16: 4066-218. PMID: 19754423
- Molecular model of anticonvulsant drug binding to the voltage-gated sodium channel inner pore. | Lipkind, GM. and Fozzard, HA. 2010. Mol Pharmacol. 78: 631-8. PMID: 20643904
- Carbamazepine, carbamazepine epoxide and dihydroxycarbamazepine sorption to soil and occurrence in a wastewater reuse site in Tunisia. | Fenet, H., et al. 2012. Chemosphere. 88: 49-54. PMID: 22443929
- The interaction between carbamazepine and erythromycin. | Turner, PV. and Renton, KW. 1989. Can J Physiol Pharmacol. 67: 582-6. PMID: 2776076
- Fabrication of Carbamazepine Cocrystals: Characterization, In Vitro and Comparative In Vivo Evaluation. | Wasim, M., et al. 2021. Biomed Res Int. 2021: 6685806. PMID: 33816628
- LC-MS3 Strategy for Quantification of Carbamazepine in Human Plasma and Its Application in Therapeutic Drug Monitoring. | Ma, D., et al. 2022. Molecules. 27: PMID: 35209012
- Quantification of 10,11-dihydro-10-hydroxy carbamazepine and 10,11-epoxycarbamazepine as the main by-products in the electrochemical degradation of carbamazepine. | Mussa, ZH. and Al-Qaim, FF. 2022. Environ Sci Pollut Res Int. 29: 62447-62457. PMID: 35397035
- Insightful vibrational imaging study on the hydration mechanism of carbamazepine. | Fateixa, S., et al. 2022. Phys Chem Chem Phys. 24: 19502-19511. PMID: 35938321
- Carbamazepine metabolism in man. Induction and pharmacogenetic aspects. | Eichelbaum, M., et al. 1985. Clin Pharmacokinet. 10: 80-90. PMID: 3971637
- Carbamazepine 10,11-epoxide in children. | Rylance, GW., et al. 1984. Br J Clin Pharmacol. 18: 935-9. PMID: 6529533
- Carbamazepine and its metabolites in neuralgias: concentration-effect relations. | Moosa, RS., et al. 1993. Eur J Clin Pharmacol. 45: 297-301. PMID: 8299659
Inhibitor of:
ABHD6, COPT2, CYP1A2, CYP27B1, IMP-3, IMPA3, KIR3.4, LGI2, LRFN5, MrgB4, MRGF, Myo-inositol monophosphatase 1, Na+ CP type IIIα, Na+ CP type IIIβ, Na+ CP type IVα, Neuron navigator 1, Olfr825, Olr213, Olr235, PCP-2, PNKD, Rit2, SCNM1, SCP2, SHISA4, Sodium Channel Protein, sodium channel type I, sodium channel type II, sodium channel type III, sodium channel type IV, T2R26, Unc79, and V1RB8.Activator of:
5330417C22Rik, 5430411K18Rik, Atg14, Atg2A, Atg9b, Aut7, Ces1g, Cvt19, CYP20A1, CYP27C1, CYP2B1, CYP2B2, CYP2B23, CYP2B6, CYP2C18, Cyp2c38, Cyp2c40, Cyp2c65, CYP2D12, CYP2D6, CYP2F1, CYP2J9, CYP2U1, CYP3A1, Cyp3a13, Cyp3a18, CYP3A4, Cyp3a41b, CYP3A43, Cyp3a44, CYP3A5, CYP3A7, CYP3A7-CYP3AP1, CYP4F12, CYP4V2, CYP7B1, DRAM2, Gm104, HCP1, IMPA1, IMPA2, IP3KA, KCNQ2, KCNT2, LGI1, MB67_CAR1/2, mEH, MIP-T3, MTHFS, MUDENG, Myo-inositol monophosphatase 1, Na+ CP type Iβ, Na+ CP type VIIα, NRBF2, NTCP, OAT, PCP4L1, PNMAL1, PXR, SLC43A2, sodium channel type II, SV2A, TMEM166, UGT2B7, VACVase, VKORC1, WDFY3, and WIPI-4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Carbamazepine, 1 g | sc-202518 | 1 g | $32.00 | |||
Carbamazepine, 5 g | sc-202518A | 5 g | $70.00 |