Molecular structure of Butein, CAS Number: 487-52-5
Butein (CAS 487-52-5)
See product citations (8)
Alternate Names:
2′,3,4,4′-Tetrahydroxychalcone
Application:
Butein is inhibits the tyrosine kinase activity of the EGF receptor and p60c-src
CAS Number:
487-52-5
Purity:
≥95%
Molecular Weight:
272.25
Molecular Formula:
C15H12O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Butein is a plant polyphenol that acts as a specific protein tyrosine kinase inhibitor. Butein potently inhibits the tyrosine kinase activity of the EGF receptor (IC50 = 65 muM) and p60c-src (IC50 = 65 muM). The inhibition is competitive with respect to ATP and non-competitive with respect to the substrate. Butein is also a potent antioxidant and antiinflammatory agent which may act to inhibit glutathione reductase and rat liver GST (glutathione-S-transferase (IC50 = 9 muM)). Butein has been reported to activate sirtuins and promote the survival of eukaryotic cells. The Sirtuins, SIRT1-4 and SIRT7 are deacetylases relevant to histone modification. Butein directly inhibits IKK and suggested to also display inhibition towards PDE (c-AMP dependent PDE-IV). Also a potential CYP19 (Aromatase) inhibitor.
Butein (CAS 487-52-5) References
- Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. | Howitz, KT., et al. 2003. Nature. 425: 191-6. PMID: 12939617
- Butein attenuates the cytotoxic effects of LPS-stimulated microglia on the SH-SY5Y neuronal cell line. | Liu, Y., et al. 2020. Eur J Pharmacol. 868: 172858. PMID: 31837307
- Butein inhibits lipogenesis in Caenorhabditis elegans. | Farias-Pereira, R., et al. 2020. Biofactors. 46: 777-787. PMID: 32663368
- The Protective Roles of Butein on Indomethacin Induced Gastric Ulcer in Mice. | Ugan, RA. and Un, H. 2020. Eurasian J Med. 52: 265-270. PMID: 33209079
- Butein induces cellular senescence through reactive oxygen species-mediated p53 activation in osteosarcoma U-2 OS cells. | Hsu, YK., et al. 2021. Environ Toxicol. 36: 773-781. PMID: 33325610
- Effects of butein on renal ischemia/reperfusion injury: An experimental study. | Ramazanoglu, MA., et al. 2020. Arch Ital Urol Androl. 92: PMID: 33348962
- Butein Inhibits Oxidative Stress Injury in Rats with Chronic Heart Failure via ERK/Nrf2 Signaling. | Liu, P. and Pan, Q. 2022. Cardiovasc Ther. 2022: 8684014. PMID: 35069800
- Effects of butein on human osteosarcoma cell proliferation, apoptosis, and autophagy through oxidative stress. | Zhang, P., et al. 2022. Hum Exp Toxicol. 41: 9603271221074346. PMID: 35130734
- Butein Ameliorates Oxidative Stress in H9c2 Cardiomyoblasts through Activation of the NRF2 Signaling Pathway. | Tungalag, T., et al. 2022. Antioxidants (Basel). 11: PMID: 35892632
- Butein promotes ubiquitination-mediated survivin degradation inhibits tumor growth and overcomes chemoresistance. | Dong, X., et al. 2022. Sci Rep. 12: 20644. PMID: 36450751
- Butein inhibits corticosterone-induced apoptosis of Neuro2A cells by maintaining MEK-ERK signaling. | Ohmoto, M., et al. 2023. IBRO Neurosci Rep. 14: 447-452. PMID: 37252631
- Inhibitory effects of plant polyphenols on rat liver glutathione S-transferases. | Zhang, K. and Das, NP. 1994. Biochem Pharmacol. 47: 2063-8. PMID: 8010991
- Inhibition of glutathione reductase by plant polyphenols. | Zhang, K., et al. 1997. Biochem Pharmacol. 54: 1047-53. PMID: 9374426
- Three new flavonoids and antiallergic, anti-inflammatory constituents from the heartwood of Dalbergia odorifera. | Chan, SC., et al. 1998. Planta Med. 64: 153-8. PMID: 9525107
- Butein, a specific protein tyrosine kinase inhibitor. | Yang, EB., et al. 1998. Biochem Biophys Res Commun. 245: 435-8. PMID: 9571170
Inhibitor of:
AP-2α, CYP19, EGFR, Glutathione reductase, GST, IKK, PDE, and Tyrosine Kinase.Activator of:
CRB3, DnaJC5B, HoxA2, and SIRT1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Butein, 5 mg | sc-202510 | 5 mg | $172.00 | |||
Butein, 50 mg | sc-202510A | 50 mg | $306.00 |