Benzamide (CAS 55-21-0)
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Benzamide is the amide derivative of benzoic acid and an inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1). Benzamide mimics the structure of the nicotinamide portion of the coenzyme NAD+, blocking the function of ADP-ribose transfer from NAD+ to target histone proteins performed by PARP and impeding formation of the poly(ADP-ribose) polymer. PARP activation in response to DNA strand breaks can lead to deleterious depletion of cellular NAD+, and Benzamide was shown to block NMDA- and NO-mediated neurotoxicity in rat brain through PARP inhibition. Benzamide is further demonstrated to partially prevent decreases in striatal levels of NAD+ and ATP produced by neurotoxic amounts of kainic acid.
Benzamide (CAS 55-21-0) References
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Benzamide, 5 g | sc-202494 | 5 g | $19.00 | |||
Benzamide, 25 g | sc-202494A | 25 g | $31.00 |