Molecular structure of 2-Hydroxymyristic acid, CAS Number: 2507-55-3
2-Hydroxymyristic acid (CAS 2507-55-3)
See product citations (6)
Application:
2-Hydroxymyristic acid is a protein myristoylation inhibitor
CAS Number:
2507-55-3
Purity:
>97%
Molecular Weight:
244.4
Molecular Formula:
C14H28O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
2-Hydroxymyristic acid has the capability to distinguish between myristoylation and palmitoylation, and is therefore able to inhibit protein myristoylation in cells. Many proteins require myristoylation to be fully active, and inhibition of myristoylation by 2-Hydroxymyristic acid will suppress full protein activity. Metabolic activation to the CoA thioester may be required for inhibitory potency in cells. 2-Hydroxymyristic acid is also capable of reducing the quantity of p56lck, a protein partly responsible for T cell activation, available for signal transduction at the plasma membrane through its inhibition of protein N-myristoylation.
2-Hydroxymyristic acid (CAS 2507-55-3) References
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- Intracellular ellagic acid derived from goat urine DMSO fraction (GUDF) predicted as an inhibitor of c-Raf kinase. | Raj, AK., et al. 2023. Curr Mol Med.. PMID: 36642883
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- Reversible palmitoylation of the protein-tyrosine kinase p56lck. | Paige, LA., et al. 1993. J Biol Chem. 268: 8669-74. PMID: 8473310
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2-Hydroxymyristic acid, 25 mg | sc-202401 | 25 mg | $122.00 |