Puerarin (CAS 3681-99-0)
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Puerarin functions as a phytoestrogen, binding to estrogen receptors and exerting estrogenic effects in experimental models. It acts as an agonist at estrogen receptors, modulating gene expression and influencing cellular processes. Puerarin may have antioxidant properties, scavenging free radicals and reducing oxidative stress in cells. It also exhibits anti-inflammatory effects by inhibiting the production of pro-inflammatory cytokines and enzymes. At the cellular level, puerarin regulates signaling pathways involved in cell proliferation, differentiation, and apoptosis. It has been observed to modulate ion channels and neurotransmitter receptors, impacting neuronal function in experimental studies. Puerarin plays a role in modulating cellular responses and signaling pathways, contributing to its functional significance in experimental applications.
Puerarin (CAS 3681-99-0) References
- Comparison between chinese medical herb Pueraria lobata crude extract and its main isoflavone puerarin antioxidant properties and effects on rat liver CYP-catalysed drug metabolism. | Guerra, MC., et al. 2000. Life Sci. 67: 2997-3006. PMID: 11133012
- Puerarin attenuates neurological deficits via Bcl-2/Bax/cleaved caspase-3 and Sirt3/SOD2 apoptotic pathways in subarachnoid hemorrhage mice. | Zhang, Y., et al. 2019. Biomed Pharmacother. 109: 726-733. PMID: 30551525
- Puerarin inhibits inflammation and oxidative stress in dextran sulfate sodium-induced colitis mice model. | Jeon, YD., et al. 2020. Biomed Pharmacother. 124: 109847. PMID: 31981944
- Puerarin ameliorated pressure overload-induced cardiac hypertrophy in ovariectomized rats through activation of the PPARα/PGC-1 pathway. | Hou, N., et al. 2021. Acta Pharmacol Sin. 42: 55-67. PMID: 32504066
- Puerarin sensitized K562/ADR cells by inhibiting NF-κB pathway and inducing autophagy. | Liu, Q., et al. 2021. Phytother Res. 35: 1658-1668. PMID: 33141989
- Immunomodulatory activity of puerarin in RAW264.7 macrophages and cyclophosphamide-induced immunosuppression mice. | Chang, Y., et al. 2021. Immunopharmacol Immunotoxicol. 43: 223-229. PMID: 33583301
- Puerarin Ameliorates 5-Fluorouracil-Induced Intestinal Mucositis in Mice by Inhibiting JAKs. | Wang, L., et al. 2021. J Pharmacol Exp Ther. 379: 147-155. PMID: 34400527
- Puerarin alleviates cadmium-induced oxidative damage to bone by reducing autophagy in rats. | Tong, X., et al. 2022. Environ Toxicol. 37: 720-729. PMID: 34897960
- Puerarin inhibits FUNDC1-mediated mitochondrial autophagy and CSE-induced apoptosis of human bronchial epithelial cells by activating the PI3K/AKT/mTOR signaling pathway. | Wang, L., et al. 2022. Aging (Albany NY). 14: 1253-1264. PMID: 35134750
- Puerarin protects against sepsis-induced myocardial injury through AMPK-mediated ferroptosis signaling. | Zhou, B., et al. 2022. Aging (Albany NY). 14: 3617-3632. PMID: 35482440
- Puerarin Alleviates LPS-Induced H9C2 Cell Injury by Inducing Mitochondrial Autophagy. | Chang, X., et al. 2022. J Cardiovasc Pharmacol. 80: 600-608. PMID: 35881898
- Pharmacodynamic Interactions between Puerarin and Metformin in Type-2 Diabetic Rats. | Li, Z., et al. 2022. Molecules. 27: PMID: 36364022
- Metabolism of puerarin and daidzin by human intestinal bacteria and their relation to in vitro cytotoxicity. | Kim, DH., et al. 1998. Biol Pharm Bull. 21: 628-30. PMID: 9657051
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Puerarin, 5 mg | sc-202301 | 5 mg | $129.00 | |||
Puerarin, 100 mg | sc-202301A | 100 mg | $205.00 |