Molecular structure of Daidzin, CAS Number: 552-66-9
Daidzin (CAS 552-66-9)
See product citations (1)
Alternate Names:
7-O-β-D-glucopyranoside
Application:
Daidzin is a potent inhibitor of human mitochondrial aldehye dehydrogenase which demonstrates chemopreventitive activities
CAS Number:
552-66-9
Purity:
>99%
Molecular Weight:
416.38
Molecular Formula:
C21H20O9
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Daidzin is an isoflavone. Like many isoflavones, daidzin exhibits antioxidant properties, helping to neutralize free radicals and reduce oxidative stress. Daidzin is a potent inhibitor of human ALDH2 (mitochondrial aldehyde dehydrogenase 2) with an IC50 of 80 nM. This chemical is the glucoside of the isoflavone daidzein (sc-24001) found in soy bean meal (Soja hispada). Daidzein can be liberated from daidzin through hydrolysis. Daidzin has also been shown to demonstrate chemopreventive activities by inhibiting the bioactivation of carcinogenic arylamines.
Daidzin (CAS 552-66-9) References
- Daidzein and genistein but not their glucosides are absorbed from the rat stomach. | Piskula, MK., et al. 1999. FEBS Lett. 447: 287-91. PMID: 10214963
- Effects of chemoprotective agents on the metabolic activation of the carcinogenic arylamines PhIP and 4-aminobiphenyl in human and rat liver microsomes. | Hammons, GJ., et al. 1999. Nutr Cancer. 33: 46-52. PMID: 10227043
- Estrogenic activity of glycitein, a soy isoflavone. | Song, TT., et al. 1999. J Agric Food Chem. 47: 1607-10. PMID: 10564025
- The role of colonic bacteria in the metabolism of the natural isoflavone daidzin to equol. | Rafii, F. 2015. Metabolites. 5: 56-73. PMID: 25594250
- Daidzin inhibits growth and induces apoptosis through the JAK2/STAT3 in human cervical cancer HeLa cells. | Yao, Z., et al. 2021. Saudi J Biol Sci. 28: 7077-7081. PMID: 34867009
- Daidzin inhibits hepatocellular carcinoma survival by interfering with the glycolytic/gluconeogenic pathway through downregulation of TPI1. | Li, L., et al. 2022. Biofactors. 48: 883-896. PMID: 35118741
- Daidzin targets epithelial-to-mesenchymal transition process by attenuating manganese superoxide dismutase expression and PI3K/Akt/mTOR activation in tumor cells. | Yang, MH., et al. 2022. Life Sci. 295: 120395. PMID: 35181309
- Isoflavones daidzin and daidzein inhibit lipopolysaccharide-induced inflammation in RAW264.7 macrophages. | Tan, Y., et al. 2022. Chin Med. 17: 95. PMID: 35974408
- Daidzin: a potent, selective inhibitor of human mitochondrial aldehyde dehydrogenase. | Keung, WM. and Vallee, BL. 1993. Proc Natl Acad Sci U S A. 90: 1247-51. PMID: 8433985
- Daidzin decreases ethanol consumption in rats. | Heyman, GM., et al. 1996. Alcohol Clin Exp Res. 20: 1083-7. PMID: 8892531
- Daidzin and its antidipsotropic analogs inhibit serotonin and dopamine metabolism in isolated mitochondria. | Keung, WM. and Vallee, BL. 1998. Proc Natl Acad Sci U S A. 95: 2198-203. PMID: 9482862
- Metabolism of puerarin and daidzin by human intestinal bacteria and their relation to in vitro cytotoxicity. | Kim, DH., et al. 1998. Biol Pharm Bull. 21: 628-30. PMID: 9657051
- Synthesis of 13C labelled daidzein and formononetin. | Whalley, JL., et al. 1998. Bioorg Med Chem Lett. 8: 2569-72. PMID: 9873582
Inhibitor of:
1700055N04Rik, ADH4, ADH6A, Aldehyde Dehydrogenase, ALDH1A1, ALDH1A2, ALDH1B1, ALDH2, ALDH3A2, ALDH3B1, ALDH5A1, ALDH8A1, Sciellin, and ZADH1.Activator of:
Aldehyde Dehydrogenase, ALDH3B2, FAM84B, Fukutin, and GPR39.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Daidzin, 1 mg | sc-202123 | 1 mg | $71.00 | |||
Daidzin, 5 mg | sc-202123A | 5 mg | $134.00 |