Molecular structure of Docetaxel, CAS Number: 114977-28-5
Docetaxel (CAS 114977-28-5)
See product citations (16)
Alternate Names:
Docetaxel is also known as Taxotel.
Application:
Docetaxel is a semisynthetic, antimitotic, antibiotic analog of Taxol with increased antitumor properties.
CAS Number:
114977-28-5
Purity:
≥99%
Molecular Weight:
807.9
Molecular Formula:
C43H53NO14
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Docetaxel is a semi-synthetic analog of the famous microtubule-stabilizing small molecule Taxol. Taxane compounds like Docetaxel prevent the breakdown of microtubules necessary for mitotic progress, arresting the cell cycle at G2/M, leading to apoptosis. This cytotoxic activity has been widely exploited in suppressing oncogenic proliferation.
Docetaxel (CAS 114977-28-5) References
- Clinical pharmacokinetics of docetaxel. | Clarke, SJ. and Rivory, LP. 1999. Clin Pharmacokinet. 36: 99-114. PMID: 10092957
- Mitotic catastrophe and apoptosis induced by docetaxel in hormone-refractory prostate cancer cells. | Fabbri, F., et al. 2008. J Cell Physiol. 217: 494-501. PMID: 18615564
- Docetaxel in the management of prostate cancer: current standard of care and future directions. | De Dosso, S. and Berthold, DR. 2008. Expert Opin Pharmacother. 9: 1969-79. PMID: 18627334
- Tumor-Targeted Drug and CpG Delivery System for Phototherapy and Docetaxel-Enhanced Immunotherapy with Polarization toward M1-Type Macrophages on Triple Negative Breast Cancers. | Chen, L., et al. 2019. Adv Mater. 31: e1904997. PMID: 31721331
- Synthesis of Taxol and Docetaxel by Using 10-Deacetyl-7-xylosyltaxanes. | Xue, B., et al. 2020. Chem Biodivers. 17: e1900631. PMID: 31967396
- Docetaxel-induced acute myositis: a case report with review of literature. | Wongsaengsak, S., et al. 2021. J Chemother. 33: 116-121. PMID: 32619151
- Docetaxel/dimethyl-β-cyclodextrin inclusion complexes: preparation, in vitro evaluation and physicochemical characterization. | Giri, BR., et al. 2021. Drug Dev Ind Pharm. 47: 319-328. PMID: 33576707
- Docetaxel-loaded folate-modified TPGS-transfersomes for glioblastoma multiforme treatment. | Luiz, MT., et al. 2021. Mater Sci Eng C Mater Biol Appl. 124: 112033. PMID: 33947535
- Combination treatment of docetaxel with caffeic acid phenethyl ester suppresses the survival and the proliferation of docetaxel-resistant prostate cancer cells via induction of apoptosis and metabolism interference. | Fu, YK., et al. 2022. J Biomed Sci. 29: 16. PMID: 35197069
- Ccl3 enhances docetaxel chemosensitivity in breast cancer by triggering proinflammatory macrophage polarization. | Sheng, D., et al. 2022. J Immunother Cancer. 10: PMID: 35613826
- Circ_0004087 interaction with SND1 promotes docetaxel resistance in prostate cancer by boosting the mitosis error correction mechanism. | Chen, L., et al. 2022. J Exp Clin Cancer Res. 41: 194. PMID: 35659274
- Docetaxel remodels prostate cancer immune microenvironment and enhances checkpoint inhibitor-based immunotherapy. | Ma, Z., et al. 2022. Theranostics. 12: 4965-4979. PMID: 35836810
- Docetaxel-loaded M1 macrophage-derived exosomes for a safe and efficient chemoimmunotherapy of breast cancer. | Zhao, Y., et al. 2022. J Nanobiotechnology. 20: 359. PMID: 35918698
- Docetaxel suppressed cell proliferation through Smad3/HIF-1α-mediated glycolysis in prostate cancer cells. | Peng, J., et al. 2022. Cell Commun Signal. 20: 194. PMID: 36536346
Inhibitor of:
α Tubulin, α1a Tubulin, α1b Tubulin, α1c Tubulin, α3C Tubulin, α4a Tubulin, β-Tubulin, β1 Tubulin, β2A Tubulin, γ1 Tubulin, 6330407J23Rik, AChRα, AKNA, APC7, Apg12, ARMER, BCAS2, BICD2, Borealin, CAMSAP3, CapG, CCDC61, CCDC65, CSAP, Cytokeratin 15, Dynactin 3, EAN57, EG546143, FAM82B, fidgetin, FSIP1, Gar22, Gas2, GCP4, HEI-C, Katanin p60 A1, KIAA0895L_4931428F04Rik, MAP7D2, MTUS1, NF-L, nudel, Olr526, PAC2, PGCP, Pma, SAS-4, SCLIP, ST7, TFIIH p44, Thrombospondin 1, TPPP, TPPP3, trichoplein, TTLL11, Tub, and UROC28.Activator of:
β5 Tubulin, δ-tubulin, ε Tubulin, γ Tubulin, γ1 Tubulin, ANKT, Annexin V, Aurora A, C14orf80, C17orf98, C21orf59_1110004E09Rik, C9orf116, CEP135, CLASP1, EG546143, EML3, FAM110A, GCP3, HAGHL, HAUS4, Katanin p60 AL1, Katanin p80 B1, KIAA1009, KIF2A, Klp3, MAP-9, Microtubule Marker, MRCKβ, pescadillo, pierce 1, PKR, SPMIP2, SSX4, TACC3, Tektin 4, and U2 snRNP B′′.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Docetaxel, 5 mg | sc-201436 | 5 mg | $85.00 | |||
Docetaxel, 25 mg | sc-201436A | 25 mg | $325.00 | |||
Docetaxel, 250 mg | sc-201436B | 250 mg | $1072.00 |