Molecular structure of Deoxynojirimycin, CAS Number: 19130-96-2
Deoxynojirimycin (CAS 19130-96-2)
Alternate Names:
(+)-1-Deoxynojirimycin
Application:
Deoxynojirimycin is an inhibitor of α-glucosidase I and II
CAS Number:
19130-96-2
Purity:
≥98%
Molecular Weight:
163.17
Molecular Formula:
C6H13NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Deoxynojirimycin is a Maltase-glucoamylase (alpha-glucosidase I and II) inhibitor. Interferes with N-linked glycosylation. Reported to inhibit trimming of oligosaccharides upon treatment of secretory glycoprotein IgD- and IgM-producing cells. Reported to inhibit secretion of IgD. Deoxynojirimycin is an inhibitor of beta-glucosidase and Maltase-glucoamylase.
Deoxynojirimycin (CAS 19130-96-2) References
- The alpha-glucosidase inhibitor 1-deoxynojirimycin blocks human immunodeficiency virus envelope glycoprotein-mediated membrane fusion at the CXCR4 binding step. | Papandréou, MJ., et al. 2002. Mol Pharmacol. 61: 186-93. PMID: 11752220
- Synthesis of new nitrogen analogues of salacinol and deoxynojirimycin and their evaluation as glycosidase inhibitors. | Gallienne, E., et al. 2006. J Org Chem. 71: 894-902. PMID: 16438498
- Occurrence of orally administered mulberry 1-deoxynojirimycin in rat plasma. | Nakagawa, K., et al. 2007. J Agric Food Chem. 55: 8928-33. PMID: 17914870
- Inhibition of major virulence pathways of Streptococcus mutans by quercitrin and deoxynojirimycin: a synergistic approach of infection control. | Hasan, S., et al. 2014. PLoS One. 9: e91736. PMID: 24622055
- Hypoglycemic effect of deoxynojirimycin-polysaccharide on high fat diet and streptozotocin-induced diabetic mice via regulation of hepatic glucose metabolism. | Li, YG., et al. 2015. Chem Biol Interact. 225: 70-9. PMID: 25446853
- 1-Deoxynojirimycin: Occurrence, Extraction, Chemistry, Oral Pharmacokinetics, Biological Activities and In Silico Target Fishing. | Gao, K., et al. 2016. Molecules. 21: PMID: 27886092
- Antiretroviral activity of castanospermine and deoxynojirimycin, specific inhibitors of glycoprotein processing. | Sunkara, PS., et al. 1987. Biochem Biophys Res Commun. 148: 206-10. PMID: 2960321
- Deoxynojirimycin inhibits the formation of Glc3Man9GlcNAc2-PP-dolichol in intestinal epithelial cells in culture. | Romero, PA., et al. 1985. FEBS Lett. 183: 29-32. PMID: 3156765
- Antiviral effects of deoxynojirimycin (DNJ)-based iminosugars in dengue virus-infected primary dendritic cells. | Perera, N., et al. 2022. Antiviral Res. 199: 105269. PMID: 35227758
- 1-deoxynojirimycin impairs oligosaccharide processing of alpha 1-proteinase inhibitor and inhibits its secretion in primary cultures of rat hepatocytes. | Gross, V., et al. 1983. J Biol Chem. 258: 12203-9. PMID: 6226656
- Effects of the glucosidase inhibitors nojirimycin and deoxynojirimycin on the biosynthesis of membrane and secretory glycoproteins. | Peyrieras, N., et al. 1983. EMBO J. 2: 823-32. PMID: 6227481
- Inhibition of N-linked oligosaccharide trimming does not interfere with surface expression of certain integral membrane proteins. | Burke, B., et al. 1984. EMBO J. 3: 551-6. PMID: 6232135
- Glucosidase inhibitors: structures of deoxynojirimycin and castanospermine. | Hempel, A., et al. 1993. J Med Chem. 36: 4082-6. PMID: 8258831
Inhibitor of:
α-Glucosidase, β-1,3-Gal-T1, β-1,3-Gal-T2, β-1,3-Gal-T3, β-1,3-Gal-T5, β-1,3-Gal-T6, β-1,4-Gal-T1, β-1,4-Gal-T2, β-1,4-Gal-T3, β-1,4-Gal-T4, β-1,4-Gal-T5, β-1,4-Gal-T6, β-1,4-GalNAc-T, β-1,4-GalNAc-T2, β-1,4-GalNAc-T3, β-4-Gal-T4, β-FR, β-Gal, β-Galactose Dehydrogenase S, β-Galactosidase, β-glucosidase 2, β3Gn-T4, β3Gn-T6, β3Gn-T7, β3Gn-T8, β3Gn-T9, 4922502D21Rik, 4933406M09Rik, 4933434I20Rik, A530082C11Rik, AGL, AI464131, ALG10, ALG10B, ALG13, ALG14, ALG1L2, ALG2, ALG3, ALG6, ALG8, Amylase, Amylase 1a, Amylase 1b, Amylase 1c, Amylase 2, Amylase 2a3, Amylase 2a4, Amyloglucosidase, ATF-6β, B3GNTL1, BDP1, beta-glucosidase, Blood Group A1, A2 antigen, Blood Group A1, A2, A3 antigen, Blood Group AB antigen, Blood Group B antigen, Blood Group H ab antigen, Blood Group H n, Blood Group Lewis, Blood Group Lewis a, C14orf109, C1GALT1, C85492, CLEC-18, COG1, COG2, COG5, COG8, COLEC10, D730048I06Rik, D930020B18Rik, DC2_Ostc, DPAGT1, DPM1, DPM2, EDEM3, Endoglycosidase, Endoglycosidase H, EOGT_A130022J15Rik, EP58, Erd2, ERGIC-53L, FUCA1, Fucokinase, FucT-V, FucT-VI, FucT-VII, FucT-X, FucT-XI, Fukutin, FUT1, FX, GALE, galectin-13, galectin-16, galectin-2, galectin-6, galectin-8, GALK2, GalNAc-TL2, GalNAc-TL4, GalNAcT-2, GANC, GBE1, GCNT4, Ggta1, GLB1L, GLB1L3, GlcAT-I, GLG1, Glt28d2, GLT8D1, GLT8D2, Glucose Oxidase, Glucosidase I, Glucosidase II alpha, Glucosidase IIβ, Glycophorin B, GM3 Synthase, GMPPA, GNPDA2, GNPTAB, GnT-I, GnT-II, GnT-IVA, GnT-IVB, GnT-IVH, GOLGA6B, GTDC1, H2-Q8, HEXB, ISPD, ITM1, KDEL receptor 1, KDEL receptor 2, KDEL receptor 3, KDELC2, LCT, LGALS9B, LSECtin, Lunapark, LYAG, LYG2, MagT1, Maltase-glucoamylase, MAN1A1, MAN1A2, MAN1C1, MAN2A1, MAN2A2, MAN2B2, MANBA, MANEA, MANEAL, MGAT1, Mgl2, MLEC, MPDU1, Muc21, Mucin 10, Mucin 21, Mucin 22, NAGPA, O-Glycosidase, OCRL1, OST4, OST48, Phytohemagglutinin-L, PIG-G, PIG-L, PIG-O, PIG-S, PIG-Z, Pigr, PMM1, PMM2, PNGase, POFUT2, POMGnT1, POMT1, Rer1, Ribophorin I, Ribophorin II, Ricin B, rotavirus vp7, saposin, SDF-2L1, SFT2D1, Sialyltransferase 10, Sialyltransferase 7A, Sialyltransferase 7F, Siglec-10, Siglec-15, SLC35A2, SLC35A3, SLC35A4, SLC35A5, SLC35B2, SLC35B4, SLC35C1, SLC35D1, SLC35E1, SLC35E3, Snurportin-1, SPINDLY, SR-α, SSEA-1, St3Gal-I, St3Gal-II, St3Gal-IV, ST6GAL2, ST8Sia III, Sucrase-Isomaltase, sulfamidase, TAG-72, Thomsen-Friedenreich, TIS11B, TMTC1, TMTC4, TRAM, Trehalase, UAP1, UAP1L1, VIP36, XylT-II, ZG16, and ZG16B.Activator of:
α-Glucosidase, α4Gn-T, β-1,3-Gal-T2, β-4-Gal-T4, β3Gn-T5, ALG1, ALG11, ALG1L, ALG1L2, ALG5, ALG8, Amyloglucosidase, C3orf21, COG7, Endoglycosidase H, ENGase, ERGIC-53L, FAM20B, FUCA2, FucT-III, FucT-IV, FucT-XI, galectin-12, GalNAc-T17, GLT8D4, GnT-IVB, GnT-VB, GPAA1, GPT, GXYLT2, HSPA14, MAN1B1, MANBAL, MPDU1, RNA pol σ 70, SLC35F2, and SLC35F4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Deoxynojirimycin, 1 mg | sc-201369 | 1 mg | $72.00 | |||
Deoxynojirimycin, 5 mg | sc-201369A | 5 mg | $142.00 |