Molecular structure of Bupropion HCl, CAS Number: 31677-93-7
Bupropion HCl (CAS 31677-93-7)
See product citations (4)
Alternate Names:
1-(3-chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propane, monohydrochloride
Application:
Bupropion HCl is an inhibitor of dopamine and SLC6A2
CAS Number:
31677-93-7
Purity:
≥99%
Molecular Weight:
276.2
Molecular Formula:
C13H18ClNO•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Bupropion HCl is a non-selective inhibitor of dopamine and SLC6A2 (Ki values are 1.4 μM for SLC6A2, 2.8 μM for dopamine, and 45 μM for serotonin). It also inhibits neuronal nicotinic acetylcholine receptors, AChR, DAT and ST. In vitro studies of Bupropion HCl have been conducted in cell cultures and in isolated enzymes. Bupropion HCl has been found to inhibit the reuptake of norepinephrine and dopamine in vitro. Studies in isolated enzymes have found that Bupropion HCl has a variety of effects on enzymes involved in the metabolism of neurotransmitters.
Bupropion HCl (CAS 31677-93-7) References
- Attenuation of cue-induced cigarette craving and anterior cingulate cortex activation in bupropion-treated smokers: a preliminary study. | Brody, AL., et al. 2004. Psychiatry Res. 130: 269-81. PMID: 15135160
- Treating tobacco dependence: state of the science and new directions. | Lerman, C., et al. 2005. J Clin Oncol. 23: 311-23. PMID: 15637394
- 15 years of clinical experience with bupropion HCl: from bupropion to bupropion SR to bupropion XL. | Fava, M., et al. 2005. Prim Care Companion J Clin Psychiatry. 7: 106-13. PMID: 16027765
- Efficacy of bupropion and the selective serotonin reuptake inhibitors in the treatment of major depressive disorder with high levels of anxiety (anxious depression): a pooled analysis of 10 studies. | Papakostas, GI., et al. 2008. J Clin Psychiatry. 69: 1287-92. PMID: 18605812
- Alcohol significantly lowers the seizure threshold in mice when co-administered with bupropion hydrochloride. | Silverstone, PH., et al. 2008. Ann Gen Psychiatry. 7: 11. PMID: 18706108
- Convulsive liability of bupropion hydrochloride metabolites in Swiss albino mice. | Silverstone, PH., et al. 2008. Ann Gen Psychiatry. 7: 19. PMID: 18922171
- Electroencephalographic and behavioral convulsant effects of hydrobromide and hydrochloride salts of bupropion in conscious rodents. | Henshall, DC., et al. 2009. Neuropsychiatr Dis Treat. 5: 189-206. PMID: 19557114
- Preparation, Optimization, and Screening of the Effect of Processing Variables on Agar Nanospheres Loaded with Bupropion HCl by a D-Optimal Design. | Varshosaz, J., et al. 2015. Biomed Res Int. 2015: 571816. PMID: 26090423
- Influence of bupropion HCl (Wellbatrin), a novel antidepressant, on plasma levels of prolactin and growth hormone in man and rat. | Stern, WC., et al. 1979. Life Sci. 25: 1717-24. PMID: 316848
- Neurochemical and neuropharmacological investigations into the mechanisms of action of bupropion. HCl--a new atypical antidepressant agent. | Ferris, RM., et al. 1982. Adv Biochem Psychopharmacol. 31: 277-86. PMID: 6282058
- Behavioral and biochemical effects of the antidepressant bupropion (Wellbutrin): evidence for selective blockade of dopamine uptake in vivo. | Cooper, BR., et al. 1980. J Pharmacol Exp Ther. 215: 127-34. PMID: 6778989
- A comparison of the safety and efficacy of bupropion HCL and amitriptyline hcl in depressed outpatients. | Remick, RA., et al. 1982. Prog Neuropsychopharmacol Biol Psychiatry. 6: 523-7. PMID: 6819598
Inhibitor of:
AChR, CYP2A6, DAT, SLC6A2, and ST.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bupropion HCl, 50 mg | sc-201121 | 50 mg | $77.00 | |||
Bupropion HCl, 250 mg | sc-201121A | 250 mg | $292.00 |