Ellipticine (CAS 519-23-3)
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Ellipticine is an alkaloid compound naturally occurring in plants of the Apocynaceae family, predominantly used in research due to its DNA intercalating properties. It binds to nucleic acids and is particularly useful in the study of the molecular mechanisms of DNA interaction and damage. Research involving ellipticine focuses on understanding how intercalation disrupts enzymatic processes such as DNA replication and transcription. The compound is also employed in the exploration of cellular responses to DNA damage, including the activation of repair pathways and the induction of cell cycle arrest. In fields like molecular biology, ellipticine and its derivatives are investigated for their potential to modulate signal transduction pathways that are involved in the regulation of cell growth and apoptosis. This research contributes to a broader understanding of the cellular and molecular basis of mutagenesis and carcinogenesis. Furthermore, the fluorescence properties of ellipticine make it a useful tool for studying chemical-DNA interactions and for visualizing these interactions in a cellular context using fluorescence microscopy techniques.
Ellipticine (CAS 519-23-3) References
- Ellipticine increases the superhelical density of intracellular SV40 DNA by intercalation. | Chu, Y. and Hsu, MT. 1992. Nucleic Acids Res. 20: 4033-8. PMID: 1324474
- The mechanism of cytotoxicity and DNA adduct formation by the anticancer drug ellipticine in human neuroblastoma cells. | Poljaková, J., et al. 2009. Biochem Pharmacol. 77: 1466-79. PMID: 19426684
- Ellipticine induces apoptosis in T-cell lymphoma via oxidative DNA damage. | Savorani, C., et al. 2015. Leuk Lymphoma. 56: 739-47. PMID: 24898668
- Ellipticine-loaded apoferritin nanocarrier retains DNA adduct-based cytochrome P450-facilitated toxicity in neuroblastoma cells. | Indra, R., et al. 2019. Toxicology. 419: 40-54. PMID: 30914192
- Total Synthesis of Olivacine and Ellipticine via a Lactone Ring-Opening and Aromatization Cascade. | Dilek, Ö., et al. 2019. J Org Chem. 84: 7901-7916. PMID: 31117560
- Modeling the Antileukemia Activity of Ellipticine-Related Compounds: QSAR and Molecular Docking Study. | Márquez, E., et al. 2019. Molecules. 25: PMID: 31861689
- Selected ellipticine derivatives, known to target topoisomerase II, suppress the alternative lengthening of telomere (ALT) pathway in telomerase-negative cells. | Zencir, S., et al. 2020. J Cancer Res Clin Oncol. 146: 1671-1676. PMID: 32333143
- Repurposing Ellipticine Hydrochloride to Combat Colistin-Resistant Extraintestinal Pathogenic E. coli (ExPEC). | Lu, H., et al. 2020. Front Microbiol. 11: 806. PMID: 32528422
- Ellipticine derivatives interacting with model membranes. Influence of quaternarization of nitrogen-2. | Lempereur, L., et al. 1984. Biochem Pharmacol. 33: 2499-503. PMID: 6466364
- Inhibition of p53 protein phosphorylation by 9-hydroxyellipticine: a possible anticancer mechanism. | Ohashi, M., et al. 1995. Jpn J Cancer Res. 86: 819-27. PMID: 7591958
- Topoisomerase II binds to ellipticine in the absence or presence of DNA. Characterization of enzyme-drug interactions by fluorescence spectroscopy. | Froelich-Ammon, SJ., et al. 1995. J Biol Chem. 270: 14998-5004. PMID: 7797481
- Constitutive activation of the aromatic hydrocarbon receptor. | Chang, CY. and Puga, A. 1998. Mol Cell Biol. 18: 525-35. PMID: 9418899
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ellipticine, 10 mg | sc-200878 | 10 mg | $142.00 | |||
Ellipticine, 50 mg | sc-200878A | 50 mg | $558.00 |