Molecular structure of Perillic Acid, CAS Number: 23635-14-5
Perillic Acid (CAS 23635-14-5)
Application:
Perillic Acid is an apoptosis inducing agent via an increase in p21, Bax, and caspase-3 in cells
CAS Number:
23635-14-5
Purity:
95%
Molecular Weight:
166.2
Molecular Formula:
C10H14O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Perillic Acid, a metabolite of perillyl alcohol, may act to elicit cytotoxicity, induce cell cycle arrest and apoptosis via an increase in expression of p21, Bax, and caspase-3 activity in cells. This compound has also been found to be a major metabolite of d-limonene (sc-205283), a solvent of cholesterol. Perillic Acid has been noted to inhibit isoprenylation. Studies suggest that this agent has demonstrated the capacity to produce morphological changes to murine lens epithelial cells in culture and cause opacification of the lenses.
Perillic Acid (CAS 23635-14-5) References
- Effect of perillic acid, a putative isoprenylation inhibitor, on the cultured rat lens. | Cheng, QF., et al. 2001. Exp Eye Res. 73: 239-45. PMID: 11446774
- Bioconversion of limonene to increased concentrations of perillic acid by Pseudomonas putida GS1 in a fed-batch reactor. | Mars, AE., et al. 2001. Appl Microbiol Biotechnol. 56: 101-7. PMID: 11499915
- Effect of S(-) perillic acid on protein prenylation and arterial smooth muscle cell proliferation. | Ferri, N., et al. 2001. Biochem Pharmacol. 62: 1637-45. PMID: 11755117
- Pharmacokinetics of perillic acid in humans after a single dose administration of a citrus preparation rich in d-limonene content. | Chow, HH., et al. 2002. Cancer Epidemiol Biomarkers Prev. 11: 1472-6. PMID: 12433729
- Perillyl alcohol and perillic acid induced cell cycle arrest and apoptosis in non small cell lung cancer cells. | Yeruva, L., et al. 2007. Cancer Lett. 257: 216-26. PMID: 17888568
- Protective role of perillic acid against radiation-induced oxidative stress, cytokine profile, DNA damage, and intestinal toxicity in mice. | Pratheeshkumar, P., et al. 2010. J Environ Pathol Toxicol Oncol. 29: 199-212. PMID: 21303327
- Bioconversion of R-(+)-limonene to perillic acid by the yeast Yarrowia lipolytica. | Ferrara, MA., et al. 2013. Braz J Microbiol. 44: 1075-80. PMID: 24688495
- Continuous multistep synthesis of perillic acid from limonene by catalytic biofilms under segmented flow. | Willrodt, C., et al. 2017. Biotechnol Bioeng. 114: 281-290. PMID: 27530691
- Perillyl alcohol and perillic acid exert efficient action upon HSV-1 maturation and release of infective virus. | Mello, CP., et al. 2020. Antivir Ther. 25: 1-11. PMID: 31099756
- Simultaneous measurement of perillyl alcohol and its metabolite perillic acid in plasma and lung after inhalational administration in Wistar rats. | de Lima, DC., et al. 2020. Drug Test Anal. 12: 268-279. PMID: 31800149
- Intranasal administration of perillyl alcohol-loaded nanoemulsion and pharmacokinetic study of its metabolite perillic acid in plasma and brain of rats using ultra-performance liquid chromatography/tandem mass spectrometry. | da Silva Santos, J., et al. 2021. Biomed Chromatogr. 35: e5037. PMID: 33238042
- Detection of perillyl alcohol and its metabolite perillic acid in postsurgical glioblastoma tissue after intranasal administration of NEO100: illustrative case. | Schönthal, AH., et al. 2022. J Neurosurg Case Lessons. 4: PMID: 36088606
- Analysis of perillic acid in plasma by reversed-phase high-performance liquid chromatography with ultraviolet detection. | Ikechukwu Ezennia, E., et al. 1997. J Chromatogr B Biomed Sci Appl. 688: 354-8. PMID: 9061476
- Perillic acid inhibits Ras/MAP kinase-driven IL-2 production in human T lymphocytes. | Schulz, S., et al. 1997. Biochem Biophys Res Commun. 241: 720-5. PMID: 9434775
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Perillic Acid, 100 mg | sc-200841 | 100 mg | $46.00 | |||
Perillic Acid, 500 mg | sc-200841A | 500 mg | $196.00 |