Molecular structure of Manoalide, CAS Number: 75088-80-1
Manoalide (CAS 75088-80-1)
See product citations (9)
Application:
Manoalide is a potent inhibitor of PLC, PLA2, and calcium channel proteins
CAS Number:
75088-80-1
Purity:
98%
Molecular Weight:
416.55
Molecular Formula:
C25H36O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Manoalide irreversibly inhibits the enzyme phospholipase A2. This inhibition is a key point of study in the enzymatic pathways involved in lipid metabolism and cellular signaling. It is used to probe the role of phospholipase A2 in various cellular processes and to understand the structure-activity relationships governing enzyme-ligand interactions. The compound serves as a biochemical tool in experimental applications, helping to dissect complex biological pathways.
Manoalide (CAS 75088-80-1) References
- Manoalide. | Soriente, A., et al. 1999. Curr Med Chem. 6: 415-31. PMID: 10101221
- Phospholipase A2 inhibitors from marine organisms. | Potts, BC., et al. 1992. J Nat Prod. 55: 1701-17. PMID: 1294693
- Agonist-sensitive and -insensitive intracellular Ca2+ pools. Separate Ca(2+)-releasing mechanisms revealed by manoalide and benzohydroquinone. | Muallem, S., et al. 1991. Biochem J. 279 (Pt 2): 367-75. PMID: 1659378
- Inactivation of human synovial fluid phospholipase A2 by the marine natural product, manoalide. | Jacobson, PB., et al. 1990. Biochem Pharmacol. 39: 1557-64. PMID: 2337412
- Manoalide, a natural sesterterpenoid that inhibits calcium channels. | Wheeler, LA., et al. 1987. J Biol Chem. 262: 6531-8. PMID: 2437121
- Manoalide: structure-activity studies and definition of the pharmacophore for phospholipase A2 inactivation. | Glaser, KB., et al. 1989. Mol Pharmacol. 36: 782-8. PMID: 2586492
- Differential effects of manoalide on secreted and intracellular phospholipases. | Bennett, CF., et al. 1987. Biochem Pharmacol. 36: 733-40. PMID: 3103628
- Inactivation of bee venom phospholipase A2 by manoalide. A model based on the reactivity of manoalide with amino acids and peptide sequences. | Glaser, KB. and Jacobs, RS. 1987. Biochem Pharmacol. 36: 2079-86. PMID: 3111475
- Manoalide Preferentially Provides Antiproliferation of Oral Cancer Cells by Oxidative Stress-Mediated Apoptosis and DNA Damage. | Wang, HR., et al. 2019. Cancers (Basel). 11: PMID: 31487907
- Regulation of eicosanoid biosynthesis in vitro and in vivo by the marine natural product manoalide: a potent inactivator of venom phospholipases. | Mayer, AM., et al. 1988. J Pharmacol Exp Ther. 244: 871-8. PMID: 3150849
- The Configuration-Dependent Anti-Leukemic Effect of Manoalide Stereoisomers: Reignite Research Interest in these Sponge-Derived Sesterterpenoids. | Lai, KH., et al. 2021. Bioorg Chem. 114: 105150. PMID: 34328853
- Inhibition of the NLRP3 Inflammasome Activation by Manoalide Ameliorates Experimental Autoimmune Encephalomyelitis Pathogenesis. | Li, C., et al. 2022. Front Cell Dev Biol. 10: 822236. PMID: 35252186
- Inhibition of phosphoinositide-specific phospholipase C by manoalide. | Bennett, CF., et al. 1987. Mol Pharmacol. 32: 587-93. PMID: 3683364
- Cobra venom phospholipase A2 inhibition by manoalide. A novel type of phospholipase inhibitor. | Lombardo, D. and Dennis, EA. 1985. J Biol Chem. 260: 7234-40. PMID: 3997864
- Secretory phospholipase A2 inhibitors and calmodulin antagonists as inhibitors of cytosolic phospholipase A2. | Hope, WC., et al. 1993. Agents Actions. 39 Spec No: C39-42. PMID: 8273580
Inhibitor of:
Calcium Channel Protein, Fucokinase, FucU, GFOD1, GNPDA1, group II sPLA2, group IIC sPLA2, group IVB sPLA2, group IVE sPLA2, group V PLA2, group XIIA sPLA2, group XIIB sPLA2, HXK III, JMJD7, JMJD7-PLA2G4B, LYPLA1, P76, PLA1A, PLC, PLC-L, PLCδ1, and PLRP1.Activator of:
FAM83G, group IIF sPLA2, TMEM164, and TMEM35.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Manoalide, 1 mg | sc-200733 | 1 mg | $264.00 |