Molecular structure of Piceatannol, CAS Number: 10083-24-6
Piceatannol (CAS 10083-24-6)
See product citations (11)
Alternate Names:
astringinin; 3-Hydroxyresveratol; 3,5,3′,4′-Tetrahydroxystilbene
Application:
Piceatannol is an inhibitor of Syk and NF-κB activation
CAS Number:
10083-24-6
Purity:
>98%
Molecular Weight:
244.24
Molecular Formula:
C14H12O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Piceatannol is a catechol-type polyphenol. The compound may act to act as a protein-tyrosine kinase inhibitor, and preferentially inhibits Syk in comparison to Lyn in in vitro kinase assays. In MCF-10A cell studies, Piceatannol inhibited phorbol ester-induced NF-kappaB activation and cyclooxygenase-2 expression. Research indicates that Piceatannol can upregulate Fas and FasL through AFT2 and Ca2+/p38alpha MAPK-mediated activation of c-Jun pathways. Identified as a potential inhibitor of PKA, PKC, MYLK, Lck, and IKKbeta as well as an activator of SIRT1. SIRT1 is an NAD+ dependent deacetylase that is known to target histone H4. Piceatannol is an inhibitor of CaMK, JNK, IKKalpha and PI 3-kinase. Piceatannol is an activator of caspase-3.
Piceatannol (CAS 10083-24-6) References
- Piceatannol induces Fas and FasL up-regulation in human leukemia U937 cells via Ca2+/p38alpha MAPK-mediated activation of c-Jun and ATF-2 pathways. | Liu, WH. and Chang, LS. 2010. Int J Biochem Cell Biol. 42: 1498-506. PMID: 20580678
- Piceatannol, a catechol-type polyphenol, inhibits phorbol ester-induced NF-{kappa}B activation and cyclooxygenase-2 expression in human breast epithelial cells: cysteine 179 of IKK{beta} as a potential target. | Son, PS., et al. 2010. Carcinogenesis. 31: 1442-9. PMID: 20584749
- Upregulation of PD‑L1 expression by resveratrol and piceatannol in breast and colorectal cancer cells occurs via HDAC3/p300‑mediated NF‑κB signaling. | Lucas, J., et al. 2018. Int J Oncol. 53: 1469-1480. PMID: 30066852
- Biosynthesis of resveratrol and piceatannol in engineered microbial strains: achievements and perspectives. | Shrestha, A., et al. 2019. Appl Microbiol Biotechnol. 103: 2959-2972. PMID: 30798357
- Overview of Cellular Mechanisms and Signaling Pathways of Piceatannol. | Cao, Y., et al. 2020. Curr Stem Cell Res Ther. 15: 4-10. PMID: 30947674
- Piceatannol alleviate ROS-mediated PC-12 cells damage and mitochondrial dysfunction through SIRT3/FOXO3a signaling pathway. | Yang, W., et al. 2022. J Food Biochem. 46: e13820. PMID: 34132394
- Piceatannol Protects Brain Endothelial Cell Line (bEnd.3) against Lipopolysaccharide-Induced Inflammation and Oxidative Stress. | Zhou, Y., et al. 2022. Molecules. 27: PMID: 35208996
- Piceatannol antagonizes lipolysis by promoting autophagy-lysosome-dependent degradation of lipolytic protein clusters in adipocytes. | Kwon, JY., et al. 2022. J Nutr Biochem. 105: 108998. PMID: 35346829
- The anti-Toxoplasma activity of the plant natural phenolic compound piceatannol. | Jiang, Y., et al. 2022. Front Vet Sci. 9: 972500. PMID: 35982927
- Piceatannol Alleviates Clostridium perfringens Virulence by Inhibiting Perfringolysin O. | Wang, G., et al. 2022. Molecules. 27: PMID: 36014383
- Piceatannol induces apoptotic cell death through activation of caspase-dependent pathway and upregulation of ROS-mediated mitochondrial dysfunction in pancreatic cancer cells. | Çınar Ayan, İ., et al. 2022. Mol Biol Rep. 49: 11947-11957. PMID: 36260179
- Piceatannol protects rat neuron cells from oxygen-glucose deprivation reperfusion injury via regulation of GSK-3β/Nrf2 signaling pathway. | Zhang, S., et al. 2022. Zhejiang Da Xue Xue Bao Yi Xue Ban. 51: 552-562. PMID: 36581571
- Inhibition of mast cell Fc epsilon R1-mediated signaling and effector function by the Syk-selective inhibitor, piceatannol. | Oliver, JM., et al. 1994. J Biol Chem. 269: 29697-703. PMID: 7961959
Inhibitor of:
γ Enolase, 2010002M12Rik, AOAH, AQP8, ATF-2, ATP5B, ATP5J2, ATP6E1, BDCA-2, BST-1, CaMK, CCL28, CD32-C, CLEC-2I, CLEC-5A, CLEC-9A, Dendritic Cell marker, ENPP5, Fc ε RIγ, FCRLM1, Furin, Histone cluster 1 H4F, HYPK, Iba1, IKK alpha, IKK beta, IL-27Rα, JNK, LAIR-1, Lck, LEPROT, LIME, LOXL1, Mitochondrial ATP synthase (ATP5G), MYLK, NYAP2, OSCP, PI 3-kinase, PKA, PKC, Plasmacytoid DC Marker, resistin, S-100 α chain, Ser/Thr Protein Kinase, SIRP-β1, SR140, SREBP-2, Stat, Sval2, Syk, Trav9n-3, Tyrosine Kinase, V1RC24, vacuolar proton pump, VpreB, ZFP60, and ZFP677.Activator of:
26S Proteasome, 2700049P18Rik, 5830418K08Rik, 9230107M04Rik, 9230110C19Rik, AAK1, ACP2, ADAM6A, ADAM6B, Afaf, AI464131, APOBEC2, ASB-12, ATP8B5, B7-H3, B930011P16Rik, BANK1, BBX, BC026590, BChE, BTG4, C11orf1, C15orf24, C1rb, C7orf52, C8α, CAAP1, CARD 9, casein kinase Iγ3, caspase-3, CBP β, CCDC104, CCDC121, CCDC142, CCDC167, CCDC38, CCDC62, CCDC77, CD16-B, CD300C, CD300LF, CD32-B_Fc γ RIIb, CD89, CENP-VL1, CLAP, CXorf49B, CYLC1, Dectin-2, DIP2A, DUSP5, Ebi3, ESE-1, FACL6, FXYD7, GLIPR1L3, GLT6D1, GOLGA6C, GPR39, Grap, GTSF1L, HEPN1, Histone cluster 1 H3F, HS3ST2, HVEM, IGF-IIR, Integrin αL, IRAK-1, JAK1, JAK3, KIR2DS4, Klotho, LIMP II, LOC727967_BOP1, LONRF2, LRP11, LRRC14B, LRRC43, LRRIQ1, Ly-49H, Ly6G6c, LYPD6B, MCT8, MDP-1, METT11D1, MIER2, N4bp2l1, NBEAL2, NQO2, Olr1646, Olr1657, Olr168, Olr1704, Olr1718, Olr1739, ORAOV1, PARP-12, PDAP1, PDCL2, PID1, Plasmacytoid DC Marker, Plb2, PPA1, PPP1R1C, prefoldin 1, RANK, Respiratory Syncytial Virus fusion protein, RNF175, RNF183, S19BP, SEI-1, SH3YL1, Siglec-G, Sir2, SIRT1, SLA, SLC35D1, SMG9, SNX14, SPINK13, SPRYD3, SPRYD5, SPT7L, STON1-ALF, Svs2, Syk, TCL-1B, Thrombospondin 3, Trav7-1, Trim12c, TSGA10IP, UBE2F, UBL4A, UBLCP1, versican, ZBTB44, ZFP677, ZFP715, Zfp735, ZFP758, ZFP820, ZNF14, ZNF364, ZNF474, ZNF691, and ZnT-7.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Piceatannol, 1 mg | sc-200610 | 1 mg | $50.00 | |||
Piceatannol, 5 mg | sc-200610A | 5 mg | $70.00 | |||
Piceatannol, 25 mg | sc-200610B | 25 mg | $195.00 |