Esculetin (CAS 305-01-1)
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Esculetin is a coumarin analog that is extensively researched for its biological properties and its role as a natural phenolic compound. This compound is a focus in phytochemical studies for its antioxidant activity, where it is used to understand the mechanisms of oxidative stress mitigation and the potential implications for cellular protection. In the field of environmental science, esculetin may be studied for its role in plant defense mechanisms and its natural occurrence in certain ecosystems. Additionally, researchers utilize esculetin in analytical chemistry as a fluorescent probe due to its ability to emit fluorescence upon excitation, making it useful in the detection of various analytes. In biochemistry, the compound is of interest for its potential to inhibit certain enzymes, which provides insight into the regulation of metabolic pathways. Esculetin′s interactions with metal ions are also an area of study, where it can form chelates, thus allowing for investigations into its use in metal ion sensing or removal from biological systems.
Esculetin (CAS 305-01-1) References
- Binding investigation of human 5-lipoxygenase with its inhibitors by SPR technology correlating with molecular docking simulation. | Du, L., et al. 2006. J Biochem. 139: 715-23. PMID: 16672272
- Esculetin enhances TRAIL-induced apoptosis through DR5 upregulation in human oral cancer SAS cells. | Kok, SH., et al. 2009. Oral Oncol. 45: 1067-72. PMID: 19720557
- Induction of apoptosis by esculetin in human leukemia U937 cells: roles of Bcl-2 and extracellular-regulated kinase signaling. | Park, C., et al. 2010. Toxicol In Vitro. 24: 486-94. PMID: 19786087
- Intestinal anti-inflammatory activity of esculetin and 4-methylesculetin in the trinitrobenzenesulphonic acid model of rat colitis. | Witaicenis, A., et al. 2010. Chem Biol Interact. 186: 211-8. PMID: 20380826
- Esculetin regulates the phenotype switching of airway smooth muscle cells. | Xie, C., et al. 2019. Phytother Res. 33: 3008-3015. PMID: 31435973
- Esculetin protects human corneal epithelial cells from oxidative stress through Nrf-2 signaling pathway. | Zhang, Y., et al. 2021. Exp Eye Res. 202: 108360. PMID: 33220236
- Esculetin protects against early sepsis via attenuating inflammation by inhibiting NF-κB and STAT1/STAT3 signaling. | Cheng, YJ., et al. 2021. Chin J Nat Med. 19: 432-441. PMID: 34092294
- Esculetin Alleviates Acute Liver Failure following Lipopolysaccharide/D-Galactosamine in Male C57BL/6 Mice. | Mohamadi-Zarch, SM., et al. 2021. Iran J Med Sci. 46: 373-382. PMID: 34539012
- Esculetin alleviates murine lupus nephritis by inhibiting complement activation and enhancing Nrf2 signaling pathway. | Zhang, Y., et al. 2022. J Ethnopharmacol. 288: 115004. PMID: 35051603
- Esculetin inhibits the pyroptosis of microvascular endothelial cells through NF-κB /NLRP3 signaling pathway. | Ren, W., et al. 2022. Arch Biochem Biophys. 720: 109173. PMID: 35300940
- Esculetin has therapeutic potential via the proapoptotic signaling pathway in A253 human submandibular salivary gland tumor cells. | Park, SB., et al. 2022. Exp Ther Med. 24: 533. PMID: 35837055
- Antioxidant Efficacy of Esculetin against Tert-Butyl Hydroperoxide-Induced Oxidative Stress in HEK293 Cells. | Jung, WK., et al. 2022. Curr Issues Mol Biol. 44: 5986-5994. PMID: 36547068
- Inhibitory effect of esculetin on 5-lipoxygenase and leukotriene biosynthesis. | Neichi, T., et al. 1983. Biochim Biophys Acta. 753: 130-2. PMID: 6411127
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Esculetin, 1 g | sc-200486 | 1 g | $43.00 | |||
Esculetin, 5 g | sc-200486A | 5 g | $208.00 |