Molecular structure of Arcaine sulfate, CAS Number: 14923-17-2
Arcaine sulfate (CAS 14923-17-2)
Alternate Names:
1,4-Diguanidinobutane sulfate salt
Application:
Arcaine sulfate is a novel and potent antagonist of the polyamine site on the NMDA receptor
CAS Number:
14923-17-2
Molecular Weight:
270.31
Molecular Formula:
C6H16N6•H2SO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Arcaine is a novel and potent antagonist of the polyamine site on the NMDA receptor. It can produce a parallel shift in the response to spermidine, differentiating arcaine from other polyamine antagonists. In the absence of added polyamines, it can inhibit [3H]MK801 binding. It has been reported to linearly inhibit nitric oxide synthase (NOS) in rat brains. The potency of arcaine may be decreased by various cations including Ca2+, Ba2+, and Sr2+.
Arcaine sulfate (CAS 14923-17-2) References
- Histamine facilitates in vivo thalamocortical long-term potentiation in the mature visual cortex of anesthetized rats. | Kuo, MC. and Dringenberg, HC. 2008. Eur J Neurosci. 27: 1731-8. PMID: 18371073
- Arcaine uncovers dual interactions of polyamines with the N-methyl-D-aspartate receptor. | Reynolds, IJ. 1990. J Pharmacol Exp Ther. 255: 1001-7. PMID: 2148185
- Arcaine is a competitive antagonist of the polyamine site on the NMDA receptor. | Reynolds, IJ. 1990. Eur J Pharmacol. 177: 215-6. PMID: 2155812
- Inhibitory effect of arcaine on nitric oxide synthase in the rat brain. | Kabuto, H., et al. 1995. Neuroreport. 6: 554-6. PMID: 7539305
Inhibitor of:
NMDA, and NOS.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Arcaine sulfate, 20 mg | sc-200475 | 20 mg | $70.00 | |||
Arcaine sulfate, 50 mg | sc-200475A | 50 mg | $74.00 |