Molecular structure of Antibiotic A-23187, 4-Bromo, CAS Number: 76455-82-8
Antibiotic A-23187, 4-Bromo (CAS 76455-82-8)
Alternate Names:
Antibiotic A-23187, 4-bromo
Application:
Antibiotic A-23187, 4-Bromo is a very selective calcium ionophore
CAS Number:
76455-82-8
Purity:
98%
Molecular Weight:
602.5
Molecular Formula:
C29H36BrN3O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Antibiotic A-23187, 4-Bromo is a divalent cation-specific, ionophoretic antibiotic that acts as a channel for cations such as Mn2+, Ca2+, and Mg2+. In addition, this antibiotic is produced by Streptomyces chartreusensis to combat against gram-positive bacteria. Studies suggest that Antibiotic A-23187, 4-Bromo is widely used to increase intracellular free Ca2+ concentration in cells. Furthermore, Antibiotic A-23187, 4-Bromo promotes the equilibration of [Ca2+] gradients between cellular compartments, including the ER, mitochondria and cytosol. In axons, a modest mitochondrial depolarization is amplified in the presence of A-23187 and is suppressed in the absence of extracellular Ca2+.
Antibiotic A-23187, 4-Bromo (CAS 76455-82-8) References
- Effects of magnesium, Ruthenium red and the antibiotic ionophore A-23187 on initial rates of calcium uptake and release by heart mitochondria. | Sordahl, LA. 1975. Arch Biochem Biophys. 167: 104-15. PMID: 1093479
- Microbial transformation of A23187, a divalent cation ionophore antibiotic. | Abbott, BJ., et al. 1979. Antimicrob Agents Chemother. 16: 808-12. PMID: 119484
- Actions of ionomycin, 4-BrA23187 and a novel electrogenic Ca2+ ionophore on mitochondria in intact cells. | Abramov, AY. and Duchen, MR. 2003. Cell Calcium. 33: 101-12. PMID: 12531186
- Calcium transport by ionophorous peptides in dog and human lymphocytes detected by quin-2 fluorescence. | Deber, CM. and Hsu, LC. 1986. Biochem Biophys Res Commun. 134: 731-5. PMID: 3947349
- Activity-dependent development of calcium regulation in growing motor axons. | Lnenicka, GA., et al. 1998. J Neurosci. 18: 4966-72. PMID: 9634562
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Antibiotic A-23187, 4-Bromo, 1 mg | sc-200193 | 1 mg | $112.00 |