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Monensin Sodium Salt (CAS 22373-78-0)

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Alternate Names:
Monensin Na; Rumensin
Application:
Monensin Sodium Salt is a monovalent cation ionophore and transporter
CAS Number:
22373-78-0
Purity:
≥90%
Molecular Weight:
692.86
Molecular Formula:
C36H61O11•Na
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Monensin Sodium Salt, a polyether antibiotic derived from Streptomyces cinnamonensis, operates primarily by forming complexes with monovalent cations such as Na+ and K+, facilitating their transport across biological membranes. This unique mechanism underlies its role as a potent ionophore, especially in research related to ion transport and cellular homeostasis. In the realm of scientific investigation, Monensin Sodium Salt has been pivotal in studies focusing on intracellular ion regulation, endosomal acidification, and the elucidation of cellular processes such as autophagy and apoptosis. Its ability to disrupt ion gradients across membranes not only serves as a tool for probing fundamental cellular functions but also aids in the study of ion-dependent signaling pathways. By altering ion concentration within cells, Monensin Sodium Salt provides researchers with a method to dissect the intricate mechanisms governing cellular physiology, making it an invaluable asset in the advancement of molecular biology and biochemistry research endeavors.


Monensin Sodium Salt (CAS 22373-78-0) References

  1. Synthesis and antimicrobial properties of monensin A esters.  |  Huczyński, A., et al. 2008. Bioorg Med Chem Lett. 18: 2585-9. PMID: 18375122
  2. Alteration of intracellular traffic by monensin; mechanism, specificity and relationship to toxicity.  |  Mollenhauer, HH., et al. 1990. Biochim Biophys Acta. 1031: 225-46. PMID: 2160275
  3. Effect of the granulometric characteristics of monensin sodium on controlling experimental coccidiosis in broiler chickens.  |  Rambozzi, L., et al. 2012. Rev Bras Parasitol Vet. 21: 60-4. PMID: 22534947
  4. Effect of increasing monensin sodium levels in diets with virginiamycin on the finishing of Nellore cattle.  |  Benatti, JMB., et al. 2017. Anim Sci J. 88: 1709-1714. PMID: 28557191
  5. Safety and efficacy of Monimax® (monensin sodium and nicarbazin) for turkeys for fattening.  |  , ., et al. 2017. EFSA J. 15: e05094. PMID: 32625380
  6. Safety and efficacy of Monimax® (monensin sodium and nicarbazin) for chickens for fattening and chickens reared for laying.  |  , ., et al. 2018. EFSA J. 16: e05459. PMID: 32625743
  7. Safety for the environment of Monimax® (monensin sodium and nicarbazin) for chickens for fattening, chickens reared for laying and for turkeys for fattening.  |  , ., et al. 2019. EFSA J. 17: e05888. PMID: 32626175
  8. Safety and efficacy of Elancoban® G200 (monensin sodium) for chickens for fattening, chickens reared for laying and turkeys.  |  , ., et al. 2019. EFSA J. 17: e05891. PMID: 32626196
  9. A novel cell culture system modeling the SARS-CoV-2 life cycle.  |  Ju, X., et al. 2021. PLoS Pathog. 17: e1009439. PMID: 33711082
  10. Comparison of monensin sodium sources for finishing beef cattle.  |  Husz, TC., et al. 2021. Transl Anim Sci. 5: txab090. PMID: 34124593
  11. Can phytogenic additives replace monensin sodium in beef cattle feeding?  |  de Sá Assis, MC., et al. 2023. Trop Anim Health Prod. 55: 107. PMID: 36913161
  12. Molecular structure of monovalent metal cation complexes of monensin.  |  Pinkerton, M. and Steinrauf, LK. 1970. J Mol Biol. 49: 533-46. PMID: 5453344
  13. Accidental monensin sodium intoxication of feedlot cattle.  |  Schweitzer, D., et al. 1984. J Am Vet Med Assoc. 184: 1273-6. PMID: 6735846
  14. Delayed monensin sodium toxicity in horses.  |  Muylle, E., et al. 1981. Equine Vet J. 13: 107-8. PMID: 7250099

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Monensin Sodium Salt, 1 g

sc-200109
1 g
$75.00

Dear Sir or Madam, We are an importer/reseller in Brazil and interested in Monensin 40% and 90% . Potential around 100 tons/year. Do you produce it ? Thanks and regards

Asked by: Maucamram
Thank you for your question. This quantity is beyond our scope to provide.
Answered by: Technical Support
Date published: 2019-02-23

What is the expiration date?

Asked by: Ellen
Thank you for your question. Manufacturing, expiration, and retest dates are not provided on our Certificates of Analysis for list products, although, all of our products are warrantied for one year from the date purchased. Please contact our Technical Service department for additional questions at (800) 457-3801 option 2, email scbt@scbt.com, or contact us by live chat.
Answered by: Technical Support
Date published: 2016-12-14
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Rated 5 out of 5 by from Lavine and Arrizabalaga (PMCID PMC3405052)Lavine and Arrizabalaga (PMCID PMC3405052) tested the sensitivity of Toxoplasma gondii to monensin. They found that monensin treatment leads to atuophagy. -SCBT Publication Review
Date published: 2015-06-04
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Monensin Sodium Salt is rated 5.0 out of 5 by 1.
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