zygin 1 Inhibitors
Chemical inhibitors of zygin 1 can exert their effects by various modes of action, primarily by targeting the cytoskeletal components that are crucial for the protein's function in neuronal development. Colchicine, for instance, disrupts microtubule polymerization, a process essential for intracellular transport and cell shape maintenance. By binding to tubulin, colchicine inhibits the proper assembly of microtubules, which zygin 1 relies on for axonal outgrowth. Similarly, nocodazole impairs microtubule assembly by binding to β-tubulin, which can inhibit zygin 1's function in neuronal development. Paclitaxel, on the other hand, has an opposite effect on microtubules; it stabilizes them and prevents their disassembly. This hyperstabilization can also disrupt the dynamic balance required for microtubule functions associated with axonal outgrowth where zygin 1 is active.
The actin cytoskeleton is another target of zygin 1 inhibitors. Latrunculin A and cytochalasin D interfere with actin polymerization but through different mechanisms. Latrunculin A binds to actin monomers, thus preventing their polymerization, whereas cytochalasin D binds to the barbed ends of actin filaments, preventing elongation. Both actions result in the inhibition of zygin 1, which requires an organized actin cytoskeleton for neurite outgrowth. In contrast, jasplakinolide and phalloidin stabilize actin filaments, which equally disrupts zygin 1 function by preventing the necessary cytoskeletal rearrangements. Additionally, zygin 1's function can be influenced by compounds that affect the actin-myosin interaction; blebbistatin inhibits myosin II ATPase activity, and ML-7 targets myosin light chain kinase. Furthermore, Y-27632 and SMIFH2 disrupt the actin cytoskeleton by preventing stress fiber formation and formin-mediated actin assembly, respectively, while CK-636 inhibits the Arp2/3 complex, which is involved in the nucleation of new actin filaments. Each of these diverse mechanisms can impact zygin 1's role in the structural dynamics of neurons.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Colchicine binds to tubulin, disrupting microtubule polymerization, which is essential for various intracellular transport mechanisms. Given that zygin 1 is involved in axonal outgrowth and may rely on microtubule-based transport, colchicine's action can inhibit zygin 1's function by destabilizing the cytoskeletal architecture it depends on. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $260.00 $799.00 | 36 | |
Latrunculin A binds to actin monomers and prevents their polymerization. Zygin 1, which plays a role in neurite extension, requires a properly organized actin cytoskeleton. By disrupting actin filaments, latrunculin A can inhibit the function of zygin 1 in neurite outgrowth. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole interferes with microtubule assembly by binding to β-tubulin. Zygin 1's function in axonal growth and guidance could be inhibited as nocodazole disrupts microtubules, which are integral to zygin 1's role in neuronal development. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Paclitaxel stabilizes microtubules and prevents their disassembly. This hyperstabilization can inhibit zygin 1 by disrupting the dynamic balance required for microtubule functions associated with axonal outgrowth and synaptic function where zygin 1 is active. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $145.00 $442.00 | 64 | |
Cytochalasin D binds to the barbed ends of actin filaments, preventing their elongation. Zygin 1's involvement in cytoskeletal reorganization and neurite outgrowth is dependent on actin dynamics, thus, inhibition by cytochalasin D can impair zygin 1 function. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $179.00 $307.00 $455.00 $924.00 $1689.00 | 7 | |
Blebbistatin inhibits myosin II ATPase activity, which is crucial for muscle contraction and cell motility. Zygin 1, which is implicated in neuronal development, may be functionally inhibited by blebbistatin due to its role in actomyosin-driven processes. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a ROCK inhibitor that compromises the actin cytoskeleton by preventing stress fiber formation. Zygin 1, which requires cytoskeletal integrity for its function in neurons, could be inhibited by the disruptions caused by Y-27632. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $89.00 $262.00 | 13 | |
ML-7 inhibits myosin light chain kinase (MLCK), which is involved in actin-myosin contraction. By inhibiting MLCK, ML-7 can impede the cellular processes involving cytoskeletal dynamics that zygin 1 needs for its function in neuron structuring. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $180.00 $299.00 | 59 | |
Jasplakinolide stabilizes actin filaments and prevents their disassembly. This disrupts actin dynamics, which can inhibit zygin 1's role in neurite outgrowth by preventing necessary cytoskeletal rearrangements. | ||||||
SMIFH2 | 340316-62-3 | sc-507273 | 5 mg | $140.00 | ||
SMIFH2 is a formin inhibitor that disrupts the formation of long actin filaments. Zygin 1's function is closely tied to the dynamics of actin, and by inhibiting formin-mediated actin assembly, SMIFH2 can inhibit the action of zygin 1 in neuronal cells. | ||||||