Zwilch Inhibitors
Zwilch inhibitors are chemical compounds designed to specifically inhibit the function of the Zwilch protein, which is an essential component of the kinetochore, a complex of proteins involved in chromosome segregation during cell division. Zwilch is a part of the RZZ (Rod, Zwilch, and ZW10) complex, which plays a key role in the spindle assembly checkpoint (SAC). This checkpoint ensures that chromosomes are properly aligned and attached to the mitotic spindle before anaphase begins, preventing errors in chromosome segregation that can lead to aneuploidy. Zwilch is critical for recruiting other key kinetochore proteins and for regulating the activity of the SAC, making it a central player in maintaining the accuracy of mitosis.
Inhibitors of Zwilch function by targeting this protein's role within the RZZ complex, potentially disrupting its ability to facilitate proper chromosome alignment and spindle attachment. By inhibiting Zwilch, these compounds interfere with the recruitment of other kinetochore proteins and impair the spindle assembly checkpoint, which can lead to altered mitotic progression. This inhibition can affect the fidelity of chromosome segregation, offering valuable insights into the mechanistic role of Zwilch in mitosis and the overall maintenance of genomic stability. Researchers use Zwilch inhibitors to study the molecular dynamics of kinetochore function and to explore how disruptions in chromosome segregation mechanisms contribute to broader cellular processes. These inhibitors provide a powerful tool for dissecting the complex protein interactions and checkpoints that govern cell division, shedding light on the critical roles that Zwilch and the RZZ complex play in mitotic regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A may downregulate Zwilch expression by inhibiting histone deacetylase, leading to hyperacetylation of histones near the Zwilch gene promoter. This hyperacetylation could prevent transcriptional activators from binding to the promoter region, thereby decreasing the transcription of the Zwilch gene. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine could decrease Zwilch expression by reducing the methylation levels of the gene's promoter, which may silence the gene's transcriptional activity. Demethylation can lead to the recruitment of transcriptional repressors to the Zwilch promoter, resulting in a decline in Zwilch protein synthesis. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Suberoylanilide Hydroxamic Acid might reduce Zwilch expression through the inhibition of histone deacetylases, resulting in an open chromatin structure and the subsequent recruitment of transcriptional repressors that can bind to the acetylated histones near the Zwilch gene, thereby reducing its expression. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
5-Aza-2′-Deoxycytidine is hypothesized to downregulate Zwilch expression by inhibiting DNA methyltransferases, thereby decreasing methylation at the CpG islands of the Zwilch promoter. This could lead to the destabilization of transcription factor complexes that are essential for Zwilch gene transcription. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Disulfiram may inhibit the transcription of the Zwilch gene by chelating metal ions that are co-factors for enzymes involved in the transcription process. This chelation could hinder the proper function of these enzymes, leading to a decrease in Zwilch mRNA and protein levels. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid could decrease Zwilch expression by binding to its nuclear receptors, which may alter the expression of genes involved in cell differentiation. This binding may lead to the downregulation of transcription factors or co-activators required for Zwilch gene expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin might reduce the expression of Zwilch by inhibiting key transcriptional activators or coactivators through the suppression of NF-κB activation, which is known to participate in the control of numerous genes, including those involved in cell cycle regulation, potentially including Zwilch. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein could inhibit the expression of Zwilch by blocking tyrosine kinase signaling pathways that are upstream of transcription factors critical for Zwilch gene activation, leading to a decrease in the transcription of the Zwilch gene. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
Hydroxyurea is postulated to downregulate Zwilch expression by inhibiting ribonucleotide reductase, leading to a reduction in deoxyribonucleotide pools, which are essential for DNA synthesis and replication. This inhibition can result in a general suppression of genes involved in cell division, like Zwilch. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine could decrease Zwilch expression by disrupting endosomal acidification and lysosomal function, which may lead to the degradation of transcription factors or coactivators necessary for Zwilch gene transcription, thus reducing Zwilch protein levels. | ||||||