ZnT-7 Activators
ZnT-7 activators belong to a distinct chemical class that plays a crucial role in regulating cellular zinc transport mechanisms. These molecules are specifically designed to interact with and modulate the activity of the zinc transporter 7 (ZnT-7), a transmembrane protein responsible for the transportation of zinc ions across cell membranes. ZnT-7 itself is a member of the SLC30 family of zinc transporters, which are responsible for maintaining the intracellular zinc balance by facilitating the efflux of zinc ions from cells. ZnT-7 activators are compounds that bind to ZnT-7 and enhance its transport function, thus influencing the distribution of zinc within cells and contributing to the overall homeostasis of this essential trace metal.
The activation of ZnT-7 by these specialized compounds is of significant interest in the field of zinc biology, as it has far-reaching implications for various cellular processes. Zinc is a critical micronutrient involved in numerous biological functions, including enzymatic reactions, DNA replication, and gene expression. ZnT-7 activators, by fine-tuning the transport of zinc ions, can impact cellular zinc levels and thereby affect zinc-dependent processes. Understanding the mechanisms and properties of these activators is vital for unraveling the intricacies of zinc homeostasis and may have implications in various fields, including cell biology, metal metabolism, and the development of future applications.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
By increasing intracellular zinc levels, Zinc Pyrithione can enhance the activity of ZnT-7, which is responsible for zinc transport into the Golgi apparatus for proper functioning of zinc-dependent enzymes. | ||||||
L-Histidine | 71-00-1 | sc-394101 sc-394101A sc-394101B sc-394101C sc-394101D | 25 g 100 g 250 g 500 g 1 kg | $54.00 $84.00 $189.00 $204.00 $339.00 | 1 | |
Histidine facilitates zinc uptake which could increase the demand for ZnT-7 activity to transport zinc into the Golgi apparatus. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
Nicotinamide enhances NAD+ levels, potentially influencing ZnT-7 activity as zinc is a cofactor for sirtuin enzymes that depend on NAD+. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $69.00 $122.00 $212.00 $380.00 $716.00 | 3 | |
Involved in the reduction of oxidative stress, which can modulate zinc transporter activities including ZnT-7 to maintain cellular redox states. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Acts as an antioxidant and may modulate ZnT-7 activity as part of the cellular adaptive response to oxidative stress. | ||||||
Piceatannol | 10083-24-6 | sc-200610 sc-200610A sc-200610B | 1 mg 5 mg 25 mg | $51.00 $71.00 $199.00 | 11 | |
A hydroxylated analog of resveratrol that may similarly influence ZnT-7 activity through modulation of oxidative stress responses. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
By inhibiting zinc-dependent enzymes, Disulfiram could potentially increase the functional demand for ZnT-7 to regulate zinc homeostasis. | ||||||
Spermine | 71-44-3 | sc-212953A sc-212953 sc-212953B sc-212953C | 1 g 5 g 25 g 100 g | $61.00 $196.00 $277.00 $901.00 | 1 | |
A polyamine that can chelate zinc, potentially affecting zinc homeostasis and thus indirectly enhancing the activity of ZnT-7 to compensate. | ||||||