ZNF696 Inhibitors

Zinc finger protein 696 (ZNF696) is a member of the zinc finger protein family, characterized by the presence of zinc finger domains, which are motifs often found in DNA-binding proteins. These domains are so named because they coordinate zinc ions to stabilize their structure. Zinc finger domains consist of a sequence of amino acids that form a loop around a zinc ion, typically with the configuration of cysteine and histidine residues that bind the zinc.

ZNF696 contains multiple C2H2-type zinc fingers, which are the most common type of zinc finger domain found in eukaryotic transcription factors. Each C2H2 finger typically has a beta-beta-alpha fold that grips the zinc ion and uses the alpha helix to make contact with DNA. The specific DNA-binding properties of ZNF696 are determined by the amino acid sequence within its zinc finger domains, which dictate the protein's ability to bind to particular DNA sequences.The role of ZNF696 as a transcription factor likely involves the regulation of gene expression by binding to DNA at promoter or enhancer regions. Through such interactions, ZNF696 can potentially activate or repress the transcription of target genes, influencing diverse cellular processes, including growth, differentiation, and response to various stimuli.