ZNF684 Inhibitors
ZNF684 inhibitors are a cohort of chemical entities that indirectly diminish the functional activity of ZNF684 through interference with multiple cellular signaling pathways and processes. These inhibitors do not act directly on ZNF684 but impinge upon the pathways that influence its function. For instance, Triptolide and Curcumin undermine ZNF684 by targeting the NF-κB pathway, which is pivotal for the regulatory roles ZNF684 plays in gene transcription, potentially leading to reduced ZNF684 activity. Additionally, PD 98059 and SP600125, which act as inhibitors of the MAPK signaling cascade's components MEK and JNK, respectively, may attenuate the transcriptional programs that ZNF684 influences by altering the activity of transcription factors and signaling molecules that work in concert with ZNF684.
The PI3K/Akt and mTOR signaling pathways, known to affect transcription and translation processes that ZNF684 may regulate, are inhibited by LY 294002 and Rapamycin, respectively, thus contributing to the suppression of ZNF684's regulatory capacity. Proteasome inhibitors, such as Bortezomib and MG-132, could lead to the disruption of proteostasis and indirectly influence ZNF684's function by affecting the degradation of regulatory proteins within its network. Furthermore, Ibrutinib, by targeting Bruton's tyrosine kinase, could modify B cell receptor signaling, which has downstream effects on gene regulation that ZNF684 may be involved with. Lastly, SB 203580 and WZ4003, targeting p38 MAPK and NUAK1 respectively, could alter the cellular stress responses and metabolic pathways, potentially leading to a diminished regulatory influence of ZNF684 on gene expression patterns.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Triptolide targets the NF-κB pathway, which is intricately linked to the regulation of gene expression including that of ZNF684. By inhibiting this pathway, Triptolide likely diminishes the regulatory functions of ZNF684 in gene transcription. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD 98059 acts as a MEK inhibitor, which impedes the MAPK/ERK signaling pathway. Since ZNF684 is implicated in gene regulatory networks, inhibition of this pathway could suppress ZNF684 activity by affecting the transcriptional programs it governs. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY 294002 is a PI3K inhibitor that disrupts the PI3K/Akt signaling pathway. Given ZNF684's role in transcription regulation, dampening this pathway can lead to a decrease in ZNF684's activity by altering transcription factors and co-regulators associated with ZNF684. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR signaling, which can affect the translation of proteins governed by ZNF684's regulatory influence, thereby reducing ZNF684's functional activity in the cell. | ||||||
Thalidomide | 50-35-1 | sc-201445 sc-201445A | 100 mg 500 mg | $111.00 $357.00 | 8 | |
Thalidomide modulates the expression of multiple genes by affecting transcription factor activity. Inhibition of these transcription factors can lead to a decrease in the ZNF684-mediated gene regulation. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Bortezomib inhibits the proteasome, leading to accumulation of misfolded proteins and affecting multiple signaling pathways. This can indirectly inhibit ZNF684 by disrupting the proteostasis network that regulates its function. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG132 is another proteasome inhibitor that can lead to a general suppression of cellular regulatory mechanisms, potentially including those related to ZNF684's transcription regulatory functions. | ||||||
Ibrutinib | 936563-96-1 | sc-483194 | 10 mg | $156.00 | 5 | |
Ibrutinib is a Bruton's tyrosine kinase inhibitor potentially affecting B cell receptor signaling. B cell receptor signaling can have downstream effects on transcription factors and gene regulation, indirectly impacting ZNF684 functions. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin has been shown to interfere with multiple signaling pathways, including NF-κB, potentially affecting gene regulation by ZNF684. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK, which is part of the MAPK signaling pathway. By inhibiting JNK, this compound could indirectly inhibit ZNF684 by altering the cellular response to stress and subsequent transcription factor activity. | ||||||