ZNF662 Inhibitors

Zinc finger protein 662 (ZNF662) is a member of the zinc finger protein superfamily, which is one of the largest families of transcription factors in eukaryotic organisms. The defining feature of zinc finger proteins is their zinc finger domains, which are small, functional, independently folded units that stabilize protein structure through coordination with a zinc ion. These domains enable the protein to interact with other molecules, such as DNA, RNA, or proteins, in a sequence-specific manner.

ZNF662, like many zinc finger proteins, likely functions as a transcriptional regulator, binding to specific DNA sequences to control the expression of certain genes. The C2H2-type zinc fingers in ZNF662, which are the most common type of zinc fingers in transcription factors, consist of a short beta-sheet and an alpha-helix, with the zinc ion held in place by conserved cysteines and histidines. The alpha-helix typically contacts the major groove of the DNA, allowing for the recognition and binding of particular genetic elements.While much of ZNF662's specific biological roles and target genes remain to be fully characterized, its structural motifs suggest a role in gene regulation, potentially impacting processes like cell differentiation, growth, and response to stress. The precise DNA-binding specificity of ZNF662 is determined by the amino acid sequence within its zinc finger domains, and variations in these sequences can lead to differential gene regulation.