Date published: 2025-10-24

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ZNF624 Activators

Forskolin, known for its adeptness at stimulating adenylate cyclase, elevates cAMP levels, which in turn activate protein kinase A. This kinase holds the potential to phosphorylate ZNF624, thereby modulating its function. In parallel, 8-Br-cAMP, a mimetic of cAMP, directly triggers protein kinase A, offering a shortcut to the same destination, potentially altering the phosphorylation state of ZNF624. PMA, a potent activator of protein kinase C, and Ionomycin, which increases intracellular calcium concentrations, both create conditions for the activation of kinases that can target serine and threonine residues on proteins like ZNF624. Inhibition can also play a role in activation, as paradoxically seen with LY294002 and PD98059. By blocking PI3K and MEK, respectively, these inhibitors can induce a cascade of compensatory cellular activities that may inadvertently lead to the activation of ZNF624.

Further on this spectrum are Okadaic Acid and Calyculin A, phosphatase inhibitors that prevent the removal of phosphate groups from proteins, thus potentially keeping ZNF624 in a perpetually active state. Anisomycin steps into the fray as a stress-activated protein kinase activator, a role that implicates it in the phosphorylation and consequent activation of ZNF624. Genistein, despite its primary function as a tyrosine kinase inhibitor, has been implicated in the modulation of kinase activity beyond its intended target, potentially impacting the regulation of ZNF624. Chromatin structure and gene expression are pivotal to the activity of proteins, and herein, Trichostatin A and 5-Azacytidine emerge as influential. By inhibiting histone deacetylases and DNA methyltransferases, respectively, they can alter the transcriptional landscape, which may enhance the expression of ZNF624.

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Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Forskolin

66575-29-9sc-3562
sc-3562A
sc-3562B
sc-3562C
sc-3562D
5 mg
50 mg
1 g
2 g
5 g
$76.00
$150.00
$725.00
$1385.00
$2050.00
73
(3)

Forskolin activates adenylate cyclase, increasing cAMP levels, which can lead to the activation of PKA and subsequent phosphorylation of ZNF624.

8-Bromo-cAMP

76939-46-3sc-201564
sc-201564A
10 mg
50 mg
$97.00
$224.00
30
(1)

As a cAMP analog, 8-Br-cAMP can directly activate PKA without prior adenylate cyclase activation, potentially leading to ZNF624 phosphorylation.

PMA

16561-29-8sc-3576
sc-3576A
sc-3576B
sc-3576C
sc-3576D
1 mg
5 mg
10 mg
25 mg
100 mg
$40.00
$129.00
$210.00
$490.00
$929.00
119
(6)

PMA activates PKC, which can phosphorylate serine and threonine residues on proteins, possibly including ZNF624, altering its activity.

Ionomycin

56092-82-1sc-3592
sc-3592A
1 mg
5 mg
$76.00
$265.00
80
(4)

Ionomycin increases intracellular calcium concentration, which can activate calmodulin-dependent kinases that may act on ZNF624.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$121.00
$392.00
148
(1)

LY294002 inhibits PI3K, which can cause compensatory activation of alternative pathways that may result in ZNF624 activation.

PD 98059

167869-21-8sc-3532
sc-3532A
1 mg
5 mg
$39.00
$90.00
212
(2)

By inhibiting MEK, PD98059 can induce compensatory cellular responses that can lead to ZNF624 activation.

Okadaic Acid

78111-17-8sc-3513
sc-3513A
sc-3513B
25 µg
100 µg
1 mg
$285.00
$520.00
$1300.00
78
(4)

Okadaic Acid inhibits phosphatases, leading to increased phosphorylation of proteins, which can include ZNF624, enhancing its activity.

Calyculin A

101932-71-2sc-24000
sc-24000A
sc-24000B
sc-24000C
10 µg
100 µg
500 µg
1 mg
$160.00
$750.00
$1400.00
$3000.00
59
(3)

Similar to Okadaic Acid, Calyculin A inhibits phosphatases, potentially increasing the active phosphorylated state of ZNF624.

Anisomycin

22862-76-6sc-3524
sc-3524A
5 mg
50 mg
$97.00
$254.00
36
(2)

Anisomycin activates stress-activated protein kinases that can participate in the phosphorylation and activation of ZNF624.

Genistein

446-72-0sc-3515
sc-3515A
sc-3515B
sc-3515C
sc-3515D
sc-3515E
sc-3515F
100 mg
500 mg
1 g
5 g
10 g
25 g
100 g
$26.00
$92.00
$120.00
$310.00
$500.00
$908.00
$1821.00
46
(1)

Genistein, while primarily a tyrosine kinase inhibitor, can modulate the activity of other kinases that may influence ZNF624 activity.