ZNF566 Activators
ZNF566 can modulate its activity through various intracellular mechanisms. Forskolin, for instance, directly stimulates adenylyl cyclase, which increases the levels of cAMP within the cell. This surge in cAMP activates protein kinase A (PKA), and the activated PKA can phosphorylate ZNF566, enhancing its ability to bind DNA and activate gene transcription. Similarly, dibutyryl-cAMP, a cell-permeable analog of cAMP, can also activate PKA, leading to the phosphorylation and activation of ZNF566. On another pathway, phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC), which can then phosphorylate ZNF566, thus modulating its activity. Zinc sulfate contributes to the activation of ZNF566 by providing zinc, which is essential for the structural integrity and DNA binding activity of zinc finger proteins like ZNF566.
Other activators work by altering the chromatin landscape, making it more conducive for ZNF566 to bind to DNA. Trichostatin A and sodium butyrate are histone deacetylase inhibitors that lead to a more relaxed chromatin conformation. This change in the chromatin structure allows easier access for ZNF566 to its target binding sites on the DNA. Similarly, spermidine can facilitate chromatin remodeling, enhancing ZNF566's access to DNA. Epigallocatechin gallate (EGCG) and 5-Azacytidine reduce DNA methylation near gene loci, which can result in increased binding of ZNF566 to these regions. Resveratrol and curcumin, through different mechanisms, influence histone modification or NF-κB signaling, respectively, which can facilitate the activation of ZNF566. Retinoic acid, by binding to its nuclear receptors, can recruit ZNF566 to retinoic acid response elements on the DNA, thereby participating in the regulation of gene expression via ZNF566 activation.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, leading to an increase in cyclic AMP (cAMP) levels in cells. Elevated cAMP levels can activate protein kinase A (PKA). PKA can phosphorylate certain zinc finger proteins like ZNF566, thereby enhancing their DNA-binding activity and functional activation. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin gallate (EGCG) is a polyphenol found in green tea that has been shown to inhibit DNA methyltransferases. By inhibiting these enzymes, EGCG may reduce the methylation of DNA near gene loci, which can lead to the increased accessibility of transcription factors like ZNF566 to their target DNA sequences, enhancing their functional activation. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid binds to nuclear retinoic acid receptors (RARs) which can then bind to retinoic acid response elements (RARE) in the DNA. Proteins like ZNF566 can be recruited to these RAREs as part of a larger transcription factor complex, where ZNF566's activity is functionally activated to regulate gene expression. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP is a cell-permeable cAMP analog that activates PKA. Activation of PKA can lead to the phosphorylation of transcription factors including zinc finger proteins. The phosphorylation of ZNF566 can enhance its transcriptional activity and functional activation. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that leads to hyperacetylation of histones, causing a more open chromatin structure. This can facilitate the binding of transcription factors like ZNF566 to DNA, thereby increasing their functional activation. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate acts as a histone deacetylase inhibitor, resulting in the accumulation of acetylated histones and an open chromatin state. This can potentially enhance the DNA binding and functional activation of ZNF566 by allowing easier access to its target gene sequences. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is an inhibitor of DNA methyltransferases. By reducing DNA methylation, it can lead to the derepression of genes and allow transcription factors such as ZNF566 to access previously silenced regions of the genome, leading to their functional activation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which in turn can phosphorylate a wide range of substrates including transcription factors. Phosphorylation of ZNF566 by PKC may enhance its DNA-binding affinity and functional activation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol has been shown to modulate sirtuin activity, which can influence histone deacetylation status. By altering the chromatin state, resveratrol may support the functional activation of ZNF566 by facilitating its binding to DNA. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin is known to inhibit NF-κB signaling, which can lead to changes in the expression of a wide range of genes, including those regulating transcription factors. Through the inhibition of competing pathways, curcumin may aid in the functional activation of ZNF566 by reducing its sequestration or by allowing it enhanced access to target genes. | ||||||