ZNF492 Activators
ZNF492 can influence its function through a variety of intracellular signaling pathways and molecular mechanisms. Zinc, as an essential trace element, plays a pivotal role in the structural integrity and DNA-binding capability of ZNF492. By serving as a cofactor, zinc facilitates the proper folding of the zinc finger motifs within ZNF492, which are crucial for its interaction with DNA and the consequent transcription regulation. Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C, which can phosphorylate serine and threonine residues on proteins including transcription factors. This phosphorylation can enhance the interaction of ZNF492 with DNA or with other regulatory proteins, thus modulating its activity. Similarly, forskolin raises the levels of cyclic AMP in the cell, leading to the activation of protein kinase A, which may phosphorylate ZNF492 or its associated proteins, thereby enhancing its transcriptional regulatory functions.
Ionomycin, by increasing intracellular calcium, can activate calcium-dependent protein kinases that may phosphorylate ZNF492 or affect its protein interactions, thus modulating its activity. Retinoic acid, through its nuclear receptors, can modulate gene expression; these receptors potentially interact with ZNF492, thereby enhancing its DNA-binding efficacy. Epidermal Growth Factor (EGF), by activating its receptor, initiates a signaling cascade that can lead to the activation of kinases targeting ZNF492, enhancing its activity. Insulin can trigger phosphorylation cascades through its receptor, affecting transcription factors such as ZNF492. Histone deacetylase inhibitors like Trichostatin A and sodium butyrate can modify chromatin structure, potentially facilitating ZNF492's access to DNA. DNA methyltransferase inhibitors like 5-Azacytidine can lead to DNA demethylation, possibly increasing the accessibility of ZNF492 to DNA. Lithium chloride inhibits GSK-3 which can prevent the inhibition of transcription factors, possibly enhancing ZNF492's activity. Curcumin may modulate ZNF492's activity by altering signaling pathways or chromatin structure. Together, these chemicals can activate ZNF492 through direct or indirect mechanisms, impacting its role in regulating gene expression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc is a co-factor for ZNF492, required for the proper folding of the zinc finger motifs that enable DNA binding. By binding to the zinc finger domain, zinc ensures that ZNF492 can properly interact with its DNA targets, leading to activation of its function as a transcription factor. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which can phosphorylate serine and threonine residues on transcription factors and associated regulatory proteins. Phosphorylation by PKC may enhance the DNA-binding affinity of ZNF492 or its interaction with co-regulatory proteins, thus activating ZNF492 function. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, leading to an increase in intracellular levels of cyclic AMP (cAMP). cAMP can activate protein kinase A (PKA), which in turn might phosphorylate ZNF492 or associated regulatory proteins, thereby enhancing ZNF492's ability to regulate gene expression. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, potentially activating calcium-dependent protein kinases such as calmodulin-dependent kinase (CaMK), which could then phosphorylate ZNF492 or modulate its interaction with other proteins, leading to activation of ZNF492's DNA-binding capabilities. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid can regulate gene expression by activating its nuclear receptors. These receptors may interact with ZNF492, enhancing its ability to bind DNA or recruit co-activators for transcriptional activation, thus indirectly leading to the functional activation of ZNF492. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin can activate the insulin receptor and downstream signaling pathways such as PI3K/Akt or MAPK/ERK, which may lead to the phosphorylation and activation of transcription factors including ZNF492, thus enhancing its DNA-binding and regulatory activities. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A (TSA) is a histone deacetylase inhibitor that changes chromatin structure to a more open state, potentially facilitating the access of transcription factors like ZNF492 to their DNA-binding sites and activating their transcriptional activity. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Similar to TSA, sodium butyrate is a histone deacetylase inhibitor that can increase the accessibility of transcription factor binding sites on DNA. This may enhance the ability of ZNF492 to bind to its target genes, activating its role as a transcription factor. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor that can lead to demethylation of DNA. Hypomethylated DNA may be more accessible to transcription factors like ZNF492, potentially increasing its ability to activate transcription. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride can inhibit glycogen synthase kinase-3 (GSK-3). Inhibition of GSK-3 might prevent phosphorylation-based inhibition of transcription factors and co-activators, potentially enhancing the transcriptional activity of ZNF492. | ||||||