ZNF430 Inhibitors
ZNF430 inhibitors generally pivot around compounds that target either the zinc-finger domain characteristics or transcriptional and chromatin-remodeling processes. Zinc finger proteins are characterized by their zinc-binding domains, and their functionality often revolves around DNA binding, RNA binding, or protein-protein interactions. Agents like DTPA and TPEN are zinc chelators and, by reducing available zinc, can disrupt the structural integrity and function of zinc finger domains in proteins like ZNF430.
In terms of chromatin dynamics, Trichostatin A is an HDAC inhibitor, and its role is to maintain an open chromatin state. Given the expected role of zinc finger proteins in transcriptional regulation, agents that can modify the chromatin structure can indirectly influence ZNF430's activity. Similarly, 5-Aza-2'-deoxycytidine, a DNA methyltransferase inhibitor, affects DNA methylation, which can influence the binding of certain zinc finger proteins to DNA. BET bromodomain inhibitors, including JQ1 and I-BET151, and other epigenetic modulators, such as UNC1999 and GSK126, intervene in transcriptional regulation. They primarily target proteins that recognize specific histone marks or modify them. As many zinc finger proteins play roles in gene regulation and transcriptional control, these inhibitors can alter the landscape in which ZNF430 operates.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Diethylenetriaminepentaacetic acid | 67-43-6 | sc-214890 sc-214890A | 5 g 50 g | $75.00 $234.00 | 1 | |
Chelates metal ions and can potentially influence the metal-binding ability of zinc finger proteins. | ||||||
TPEN | 16858-02-9 | sc-200131 | 100 mg | $130.00 | 10 | |
A zinc chelator that can influence the binding properties of zinc finger domains. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Histone deacetylase inhibitor which can alter chromatin state and potentially influence ZNF430 activity. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
A DNA methyltransferase inhibitor, potentially affecting the DNA-binding of some zinc finger proteins. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
BET bromodomain inhibitor affecting transcription and may have indirect effects on ZNF430 function. | ||||||
RGFP966 | 1357389-11-7 | sc-507300 | 5 mg | $115.00 | ||
HDAC3-specific inhibitor that affects gene expression and chromatin remodeling, potentially influencing ZNF430. | ||||||
I-BET 151 Hydrochloride | 1300031-49-5 (non HCl Salt) | sc-391115 | 10 mg | $450.00 | 2 | |
BET bromodomain inhibitor, altering transcriptional programs potentially affecting ZNF430's associated functions. | ||||||
UNC1999 | 1431612-23-5 | sc-475314 | 5 mg | $142.00 | 1 | |
An inhibitor of EZH2 and EZH1, affecting methylation states and possibly interacting with pathways associated with ZNF430. | ||||||
GSK126 | 1346574-57-9 | sc-490133 sc-490133A sc-490133B | 1 mg 5 mg 10 mg | $92.00 $243.00 $306.00 | ||
EZH2 methyltransferase inhibitor affecting chromatin marks potentially influencing ZNF430 activity. | ||||||
PFI-1 | 1403764-72-6 | sc-478504 | 5 mg | $98.00 | ||
BET bromodomain inhibitor that affects gene expression and may indirectly affect ZNF430. | ||||||