Date published: 2025-10-14

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ZNF258 Inhibitors

ZNF258 inhibitors constitute a class of chemical entities designed to interact with and modulate the function of Zinc Finger Protein 258 (ZNF258), a member of the zinc finger protein family. ZNF258 is characterized by the presence of zinc finger domains, which are small protein structural motifs coordinated by one or more zinc ions. These motifs enable the protein to bind to DNA, RNA, or other proteins, facilitating a variety of biological processes, including gene expression, DNA recognition, and repair, as well as protein folding and assembly. The precise biological functions of ZNF258 are determined by the specific DNA or RNA sequences it binds to, and by its interactions with other proteins. Inhibitors that target ZNF258 are designed to selectively bind to this protein, disrupting its normal function and interactions, which can lead to alterations in the gene regulatory networks in which ZNF258 is involved.

The development of ZNF258 inhibitors involves a deep understanding of the protein's structure and binding mechanisms. These inhibitors may be small molecules, peptides, or other specialized compounds that have been engineered to interfere with the zinc finger domains or other critical regions of ZNF258. The design process typically includes a combination of computational modeling to predict how potential inhibitors might interact with ZNF258, and empirical methods such as high-throughput screening to identify compounds that demonstrate activity against the protein. Once candidate inhibitors are identified, they may be further refined to improve their selectivity for ZNF258, ensuring minimal interaction with other zinc finger proteins and reducing the potential for off-target effects.

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Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

1,10-Phenanthroline

66-71-7sc-255888
sc-255888A
2.5 g
5 g
$23.00
$31.00
(0)

Metal chelator that binds to zinc, potentially affecting the DNA-binding capacity of zinc finger proteins. By chelating zinc, the structural integrity of the zinc finger motif can be disrupted, possibly altering the function of ZNF258.

Disulfiram

97-77-8sc-205654
sc-205654A
50 g
100 g
$52.00
$87.00
7
(1)

A dithiocarbamate that can chelate zinc, thus potentially inhibiting zinc finger protein function by depriving them of their essential metal ion.

Zinc

7440-66-6sc-213177
100 g
$47.00
(0)

Zinc ionophore which can affect intracellular zinc levels, potentially impacting the function and structure of zinc finger domains in proteins like ZNF258.

5-Azacytidine

320-67-2sc-221003
500 mg
$280.00
4
(1)

DNA methyltransferase inhibitor which can impact the DNA methylation status, potentially influencing the binding and activity of transcription factors, including zinc finger proteins.

Triptolide

38748-32-2sc-200122
sc-200122A
1 mg
5 mg
$88.00
$200.00
13
(1)

Inhibitor of the XPB subunit of the transcription factor TFIIH. It can affect general transcription and potentially modulate the activity of zinc finger transcription factors indirectly.

DRB

53-85-0sc-200581
sc-200581A
sc-200581B
sc-200581C
10 mg
50 mg
100 mg
250 mg
$42.00
$185.00
$310.00
$650.00
6
(1)

A general transcription inhibitor that impacts RNA polymerase II. Given that zinc finger proteins often function in transcription, the inhibition of RNA polymerase II can indirectly modulate the potential transcriptional activity of ZNF258.

Actinomycin D

50-76-0sc-200906
sc-200906A
sc-200906B
sc-200906C
sc-200906D
5 mg
25 mg
100 mg
1 g
10 g
$73.00
$238.00
$717.00
$2522.00
$21420.00
53
(3)

Intercalates into DNA, inhibiting RNA synthesis. This can indirectly impact the function of zinc finger transcription factors by hindering their transcriptional targets.

α-Amanitin

23109-05-9sc-202440
sc-202440A
1 mg
5 mg
$260.00
$1029.00
26
(2)

Inhibitor of RNA polymerase II which can indirectly modulate the transcriptional activity of zinc finger proteins like ZNF258.

Flavopiridol Hydrochloride

131740-09-5sc-207687
10 mg
$311.00
(2)

Cyclin-dependent kinase inhibitor that can affect RNA polymerase II phosphorylation, potentially altering the transcriptional activity of zinc finger proteins.

(±)-JQ1

1268524-69-1sc-472932
sc-472932A
5 mg
25 mg
$226.00
$846.00
1
(0)

BET bromodomain inhibitor that affects transcription by disrupting the function of bromodomain-containing proteins. This can impact the broader transcriptional landscape and influence the activity of zinc finger transcription factors.