ZNF189 Activators
The chemical class of ZNF189 activators encompasses a diverse array of compounds found in natural sources such as plants and dietary sources, as well as synthetic molecules. These activators exert their effects by modulating various signaling pathways implicated in the regulation of ZNF189 expression and activity. Among these pathways are histone modification pathways, including those involving histone deacetylases (HDACs), such as Trichostatin A and sodium butyrate. These compounds function as HDAC inhibitors, leading to histone hyperacetylation, chromatin relaxation, and increased accessibility of DNA-binding sites for transcription factors such as ZNF189, thus promoting its expression.
Additionally, ZNF189 activators such as resveratrol, quercetin, and genistein target intracellular signaling pathways, including PI3K/Akt, MAPK, and NF-κB pathways, respectively. These compounds modulate the phosphorylation status and activity of key signaling molecules, leading to enhanced ZNF189-mediated transcriptional regulation. For example, resveratrol activates SIRT1/AMPK pathway, leading to histone deacetylation and alteration of chromatin structure that facilitates ZNF189 binding to target gene promoters. Quercetin inhibits PI3K/Akt signaling, reducing the phosphorylation-dependent degradation of ZNF189 or altering its interaction with regulatory proteins, thereby promoting its transcriptional activity. Similarly, genistein inhibits MAPK signaling, preventing the phosphorylation-dependent degradation of ZNF189 and enhancing its transcriptional activity.
Furthermore, ZNF189 activators like curcumin and EGCG modulate developmental signaling pathways such as Wnt/β-catenin and JAK/STAT, respectively. Curcumin inhibits Wnt/β-catenin signaling by blocking the nuclear translocation of β-catenin, while EGCG inhibits JAK/STAT signaling by suppressing STAT3 activation. These compounds ultimately promote ZNF189-mediated transcriptional regulation of target genes involved in various cellular processes, including cell proliferation, differentiation, survival, and inflammation. Overall, the chemical class of ZNF189 activators represents a promising avenue for intervention in diseases where dysregulation of ZNF189 expression and function is implicated.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A (TSA) is a potent histone deacetylase (HDAC) inhibitor. By inhibiting HDAC activity, TSA promotes histone hyperacetylation, leading to relaxation of chromatin structure and increased accessibility of DNA-binding sites. This enhanced accessibility can facilitate the binding of transcription factors, including ZNF189, to their target gene promoters, thereby upregulating ZNF189 expression and activity. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate is a short-chain fatty acid that serves as an HDAC inhibitor. Similar to TSA, sodium butyrate promotes histone hyperacetylation by inhibiting HDAC activity, resulting in chromatin relaxation and increased accessibility of DNA-binding sites for transcription factors such as ZNF189. Consequently, sodium butyrate can activate ZNF189 expression and enhance its transcriptional activity by facilitating its binding to target gene promoters. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is a natural polyphenol found in grapes, berries, and peanuts. It functions as an activator of ZNF189 by modulating various signaling pathways, including the SIRT1/AMPK pathway. Resveratrol activates SIRT1, a histone deacetylase, leading to deacetylation of histones and subsequent alteration of chromatin structure that facilitates ZNF189 binding to target gene promoters. Additionally, resveratrol activates AMPK, which can indirectly enhance ZNF189 activity by regulating cellular energy metabolism and gene expression. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is a flavonoid compound found in various fruits and vegetables. It can activate ZNF189 by modulating the PI3K/Akt signaling pathway. Quercetin inhibits PI3K activity, leading to decreased phosphorylation and activation of Akt. Inhibition of Akt signaling can enhance ZNF189 activity by reducing its phosphorylation-dependent degradation or by altering its interaction with other signaling molecules, thereby promoting ZNF189-mediated transcriptional regulation of target genes. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is an isoflavone found in soybeans and soy products. It activates ZNF189 by modulating the MAPK signaling pathway. Genistein inhibits the activity of MAPK enzymes such as ERK1/2, leading to decreased phosphorylation and activation of downstream transcription factors. This inhibition of MAPK signaling can enhance ZNF189 activity by preventing its phosphorylation-dependent degradation or by altering its interaction with other regulatory proteins, thereby promoting ZNF189-mediated transcriptional regulation of target genes. | ||||||
Kaempferol | 520-18-3 | sc-202679 sc-202679A sc-202679B | 25 mg 100 mg 1 g | $97.00 $212.00 $500.00 | 11 | |
Kaempferol is a flavonoid compound found in various fruits and vegetables. It can activate ZNF189 by modulating the NF-κB signaling pathway. Kaempferol inhibits the nuclear translocation and transcriptional activity of NF-κB, a transcription factor that can repress ZNF189 expression. By blocking NF-κB activity, kaempferol promotes ZNF189-mediated transcriptional regulation of target genes involved in various cellular processes, including proliferation, apoptosis, and inflammation. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin is a polyphenolic compound derived from the turmeric plant. It activates ZNF189 by modulating the Wnt/β-catenin signaling pathway. Curcumin inhibits the nuclear translocation of β-catenin, a key effector of Wnt signaling, thereby suppressing Wnt-dependent transcriptional activation. By inhibiting Wnt signaling, curcumin promotes ZNF189-mediated transcriptional regulation of target genes involved in cell proliferation, differentiation, and survival. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a catechin found in green tea. It can activate ZNF189 by modulating the JAK/STAT signaling pathway. EGCG inhibits the activation of STAT3, a downstream effector of JAK signaling, leading to decreased STAT3-mediated transcriptional activation. By inhibiting STAT3 signaling, EGCG promotes ZNF189-mediated transcriptional regulation of target genes involved in cell growth, differentiation, and survival. | ||||||
Piperine | 94-62-2 | sc-205809 sc-205809A | 5 g 25 g | $36.00 $143.00 | 3 | |
Piperine is an alkaloid found in black pepper. It activates ZNF189 by modulating the Hedgehog (Hh) signaling pathway. Piperine inhibits the activity of the Hh signaling effector, Gli1, leading to decreased transcriptional activation of Hh target genes. By inhibiting Hh signaling, piperine promotes ZNF189-mediated transcriptional regulation of target genes involved in cell proliferation, differentiation, and tissue development. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $90.00 | 1 | |
Berberine is an isoquinoline alkaloid found in several plants, including Berberis vulgaris. It can activate ZNF189 by modulating the mTOR signaling pathway. Berberine inhibits mTOR activity, leading to decreased phosphorylation and activation of downstream effectors such as S6K1 and 4EBP1. By inhibiting mTOR signaling, berberine promotes ZNF189-mediated transcriptional regulation of target genes involved in cell growth, metabolism, and autophagy. | ||||||