ZNF177 Activators
ZNF177 can be classified into various groups based on the mechanisms through which they enhance the protein's function. Forskolin, by directly stimulating adenylate cyclase, leads to elevated levels of cyclic AMP, which in turn activates protein kinase A (PKA). PKA is known to phosphorylate numerous substrates, including transcription factors like ZNF177, culminating in their activation. Similarly, dibutyryl-cAMP, a more cell-permeable form of cAMP, activates PKA, which subsequently phosphorylates and activates ZNF177. Phorbol 12-myristate 13-acetate (PMA) functions through a different pathway; it activates protein kinase C (PKC), which also phosphorylates and activates transcription factors, including ZNF177. Ionomycin, by increasing intracellular calcium levels, can activate calcium-dependent kinases capable of phosphorylating transcription factors, thereby potentially influencing the activation state of ZNF177.
Sodium orthovanadate inhibits phosphatases, thereby preventing the dephosphorylation and consequent deactivation of ZNF177, ensuring it remains active. Okadaic acid and Calyculin A, both inhibitors of protein phosphatases like PP1 and PP2A, similarly maintain ZNF177 in a phosphorylated and active state. Anisomycin, while known as a protein synthesis inhibitor, activates stress-activated protein kinases, which are involved in phosphorylating transcription factors, potentially affecting ZNF177's activity. Lithium chloride, by inhibiting glycogen synthase kinase-3 (GSK-3), may lead to the activation of downstream transcription factors and indirectly maintain the active form of ZNF177. Lastly, Trichostatin A, a histone deacetylase inhibitor, alters chromatin structure, thus possibly affecting the activation state of transcription factors, including ZNF177, by modifying the transcriptional environment.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylate cyclase, leading to an increase in cyclic AMP (cAMP) levels, which can activate protein kinase A (PKA). PKA can phosphorylate ZNF177, leading to its functional activation. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin gallate (EGCG) is a flavonoid found in green tea. EGCG has been shown to modulate signaling pathways that could lead to the phosphorylation of transcription factors, including those similar to ZNF177, hence directly enhancing their DNA-binding activity and functional activation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which can lead to the phosphorylation and functional activation of many proteins, including transcription factors like ZNF177. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $45.00 $56.00 $183.00 | 142 | |
Sodium orthovanadate is a phosphatase inhibitor that can prevent the dephosphorylation of proteins. By preventing the dephosphorylation of ZNF177, it can maintain ZNF177 in an activated state. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, which can activate calmodulin-dependent kinase and result in the phosphorylation and activation of transcription factors, potentially including ZNF177. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is an inhibitor of protein phosphatases PP1 and PP2A, leading to increased phosphorylation levels of many proteins. Through this mechanism, it could maintain ZNF177 in a phosphorylated and active state. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that can also activate stress-activated protein kinases (SAPKs), which have been implicated in the phosphorylation of various transcription factors, possibly influencing the activation state of ZNF177. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Calyculin A is an inhibitor of protein phosphatases, like okadaic acid, and can similarly maintain proteins in a phosphorylated state. This can contribute to the sustained activation of proteins such as ZNF177. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP is a cell-permeable analog of cAMP that can activate PKA. PKA activation can result in the phosphorylation and activation of transcription factor proteins such as ZNF177. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid can regulate gene expression through its receptors, which may include the activation of downstream transcription factors. This could lead to the activation of proteins functionally related to ZNF177. | ||||||