ZMYND17 Inhibitors

ZMYND17 inhibitors mainly comprise compounds that have an effect on chromatin remodeling, histone modification, or transcription regulation. SAHA and Trichostatin A, for instance, are histone deacetylase (HDAC) inhibitors. Their primary function is to the deacetylation of histones, which in turn can result in a more open chromatin state, influencing the functions or interactions of proteins like ZMYND17 that may be associated with chromatin.

On the other hand, compounds such as 5-Aza-2'-deoxycytidine, a DNA methyltransferase inhibitor, shed light on the DNA methylation perspective. Changes in DNA methylation states can influence gene expression and chromatin accessibility, and proteins associated with chromatin, including ZMYND17, may see a change in their activity or interaction profiles. The BET bromodomain inhibitors like JQ1 and I-BET151 bring into focus the bromodomain protein's role in recognizing acetylated lysine residues on histone tails, essential for transcription regulation. Inhibition of these proteins can lead to altered transcriptional landscapes, possibly influencing the activity or interactions of ZMYND17.