Date published: 2025-9-12

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ZFP3 Activators

Forskolin stands out as it raises intracellular cAMP, which in turn activates protein kinase A (PKA). The action of PKA is pivotal as it can phosphorylate regulatory proteins that enhance ZFP3's transcriptional activity. Similarly, IBMX works to prevent the degradation of cAMP, thus sustaining PKA activity and indirectly promoting the function of ZFP3. The calcium ionophore Ionomycin elevates intracellular calcium levels, which activates calcium-dependent kinases. These kinases have the potential to phosphorylate and thereby modulate proteins that are involved in the regulation of ZFP3. PMA, which stimulates protein kinase C (PKC), follows a related route by initiating phosphorylation events that can lead to the activation of proteins controlling ZFP3. On the epigenetic front, compounds like 5-Azacytidine and Trichostatin A target DNA and histone modification processes, respectively. 5-Azacytidine reduces DNA methylation, which can result in the upregulation of ZFP3 expression. Trichostatin A, by inhibiting histone deacetylases, can lead to a more open chromatin state, potentially facilitating increased transcription of ZFP3.

Small molecule inhibitors such as SB431542, LY294002, and U0126, despite primarily being known as inhibitors of specific signaling pathways, can indirectly increase ZFP3 activity. SB431542, for instance, inhibits TGF-β signaling, possibly resulting in the upregulation of ZFP3. LY294002 and U0126 both target the PI3K/AKT and MEK/ERK pathways, respectively, and their inhibition can lead to compensatory regulatory effects that enhance ZFP3 expression. Okadaic Acid and Thapsigargin, although they are inhibitors of protein phosphatases and the SERCA pump respectively, increase the phosphorylation state of cellular proteins and calcium levels, which can have a cascade effect on the regulation of ZFP3. PD98059, by inhibiting MEK, may also affect ZFP3 through its influence on downstream transcription factors.

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Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Forskolin

66575-29-9sc-3562
sc-3562A
sc-3562B
sc-3562C
sc-3562D
5 mg
50 mg
1 g
2 g
5 g
$76.00
$150.00
$725.00
$1385.00
$2050.00
73
(3)

Forskolin increases intracellular cAMP levels, activating PKA, which can subsequently enhance the transcriptional activity of ZFP3 by phosphorylating associated regulatory proteins.

IBMX

28822-58-4sc-201188
sc-201188B
sc-201188A
200 mg
500 mg
1 g
$159.00
$315.00
$598.00
34
(1)

IBMX inhibits phosphodiesterases, leading to increased cAMP levels, thereby activating PKA which can phosphorylate proteins involved in the regulation of ZFP3 activity.

Ionomycin

56092-82-1sc-3592
sc-3592A
1 mg
5 mg
$76.00
$265.00
80
(4)

Ionomycin raises intracellular calcium levels, activating calcium-dependent kinases that can augment ZFP3 activity through phosphorylation of regulatory proteins.

PMA

16561-29-8sc-3576
sc-3576A
sc-3576B
sc-3576C
sc-3576D
1 mg
5 mg
10 mg
25 mg
100 mg
$40.00
$129.00
$210.00
$490.00
$929.00
119
(6)

PMA activates protein kinase C (PKC) which can lead to the phosphorylation and activation of proteins that modulate ZFP3 transcriptional activity.

5-Azacytidine

320-67-2sc-221003
500 mg
$280.00
4
(1)

5-Azacytidine, a DNA methyltransferase inhibitor, can lead to the demethylation of genes and potentially increase the expression of ZFP3.

Trichostatin A

58880-19-6sc-3511
sc-3511A
sc-3511B
sc-3511C
sc-3511D
1 mg
5 mg
10 mg
25 mg
50 mg
$149.00
$470.00
$620.00
$1199.00
$2090.00
33
(3)

Trichostatin A inhibits histone deacetylases, leading to a more relaxed chromatin structure and potentially higher levels of ZFP3 transcription.

SB 431542

301836-41-9sc-204265
sc-204265A
sc-204265B
1 mg
10 mg
25 mg
$80.00
$212.00
$408.00
48
(1)

SB431542 inhibits TGF-β signaling which can lead to changes in transcriptional regulation and possibly upregulate ZFP3 expression.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$121.00
$392.00
148
(1)

LY294002 inhibits the PI3K/AKT pathway, which can result in altered transcription factor activity and possibly increase ZFP3 expression.

U-0126

109511-58-2sc-222395
sc-222395A
1 mg
5 mg
$63.00
$241.00
136
(2)

U0126 inhibits MEK, which can lead to decreased ERK activation and may cause changes in transcriptional regulation affecting ZFP3 expression.

Okadaic Acid

78111-17-8sc-3513
sc-3513A
sc-3513B
25 µg
100 µg
1 mg
$285.00
$520.00
$1300.00
78
(4)

Okadaic Acid inhibits protein phosphatases PP1 and PP2A, leading to increased phosphorylation of proteins that can enhance the transcriptional activity of ZFP3.