ZCCHC24 Activators
ZCCHC24 Activators encompass a diverse range of chemical compounds that indirectly amplify the functional activity of ZCCHC24 through discrete signaling pathways. Forskolin, 8-Bromo-cAMP, and IBMX are agents that raise intracellular cAMP levels, leading to the activation of PKA which can phosphorylate proteins that are potentially involved in modulating ZCCHC24 activity. Similarly, Calcium ionophore A23187 elevates intracellular calcium, engaging calcium-dependent kinases that may directly or indirectly phosphorylate ZCCHC24, thereby enhancing its activity. Phorbol 12-myristate 13-acetate activates PKC, which could phosphorylate substrates affecting the function of ZCCHC24, and Okadaic acid prevents dephosphorylation of proteins, which could lead to an enhanced functional state of ZCCHC24. The inhibition of competitive phosphorylation pathways by Epigallocatechin gallate could relieve negative regulation on ZCCHC24, hence increasing its activity. Sphingosine-1-phosphate signals through its receptors to activate kinases that could potentially modulate the activity of ZCCHC24 through phosphorylation cascades.
Moreover, the interaction of zinc finger domains with their cognate nucleic acid sequences is essential for the function of ZCCHC24, and this interaction can be influenced by the presence of metal ions, such as those supplied by Zinc Chloride and Copper(II) sulfate, which may modify its DNA-binding properties and consequently its activity. Nicotinamide adenine dinucleotide (NAD+), as a coenzyme, plays a role in redox reactions and can influence signaling pathways that may engage ZCCHC24, leading to its functionalactivation. Curcumin, with its broad effects on cellular signaling, has the potential to influence the phosphorylation state or conformation of proteins that interact with ZCCHC24, which would result in the potentiation of its activity. Collectively, these chemical activators, through their distinct mechanisms, converge to elevate the functional activity of ZCCHC24 without requiring changes in its expression levels or direct activation of the protein itself.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, which increases cAMP levels in cells, leading to activation of PKA. PKA can phosphorylate various substrates that may interact with or modify the activity of ZCCHC24, leading to its enhanced functional activity. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
This cAMP analog can permeate cell membranes and activate PKA. The activation of PKA can lead to the phosphorylation of proteins related to the function of ZCCHC24, thereby enhancing its activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
As a non-selective phosphodiesterase inhibitor, IBMX prevents cAMP degradation, leading to elevated cAMP levels which can activate PKA. PKA then potentially phosphorylates proteins that influence ZCCHC24 activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 increases intracellular calcium levels, which can activate calcium-dependent protein kinases that may phosphorylate and activate ZCCHC24. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which could phosphorylate substrates that modulate ZCCHC24's activity or its interaction with other proteins. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
By inhibiting protein phosphatases PP1 and PP2A, okadaic acid can lead to increased phosphorylation levels of cellular proteins, possibly affecting ZCCHC24 activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is known to inhibit certain protein kinases, thereby altering signaling pathways and potentially leading to the enhancement of ZCCHC24 activity by shifting the balance of phosphorylation. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
S1P operates through G-protein coupled receptors to activate downstream kinases that may regulate the activity of ZCCHC24. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc ions can modulate the function of zinc finger proteins like ZCCHC24 by altering their binding affinity to DNA or RNA, potentially enhancing their functional activity. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $45.00 $120.00 $185.00 | 3 | |
Copper ions can bind to proteins and influence their conformation and activity. For ZCCHC24, which has zinc finger domains, copper could potentially alter its DNA-binding properties and thus its activity. | ||||||