ZBTB7C Activators
ZBTB7C activators comprise a suite of chemical entities that indirectly promote the functional activity of ZBTB7C through various signaling cascades, thereby amplifying its biological role without affecting the protein's expression levels. Forskolin and Dibutyryl-cAMP specifically enhance ZBTB7C activity by raising intracellular cAMP levels, which activate PKA, leading to phosphorylation events that promote ZBTB7C's nuclear translocation and DNA-binding activity. Isoquercetin, through modulation of the PI3K/AKT pathway, and Indirubin, by inhibiting GSK-3β, facilitate phosphorylation cascades that result in the augmentation of ZBTB7C activity. Similarly, Tanshinone IIA and Anisomycin work via ERK1/2 and JNK pathways, respectively, to trigger downstream effects that stabilize ZBTB7C and enhance its function.
The second group of ZBTB7C activators includes compounds like Resveratrol, which activates SIRT1 to promote deacetylation processes that may increase ZBTB7C's DNA binding capacity, and Sulforaphane, which stimulates Nrf2 signaling potentially affecting ZBTB7C's activity by modulating expression of genes linked to oxidative stress responses. Curcumin contributes by inhibiting NF-κB signaling, potentially freeing up coactivators of ZBTB7C, while Retinoic acid modulates nuclear receptors that could interact with ZBTB7C, enhancing its transcriptional influence. Trichostatin A, by inhibiting histone deacetylases, leads to chromatin remodeling that could improve ZBTB7C's access to DNA, and Spermidine enhances ZBTB7C activity indirectly by promoting autophagy, which may improve the cellular environment for ZBTB7C's functional performance. Collectively, these compounds employ distinct molecular mechanisms to facilitate the enhancement of ZBTB7C-mediated regulatory processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin directly stimulates adenylate cyclase, increasing cAMP levels, which in turn activates PKA. PKA phosphorylation cascade can enhance ZBTB7C by promoting its nuclear localization and binding to target DNA sequences. | ||||||
Indirubin | 479-41-4 | sc-201531 sc-201531A | 5 mg 25 mg | $114.00 $525.00 | 4 | |
Indirubin inhibits GSK-3β, which can prevent the phosphorylation of proteins that otherwise sequester ZBTB7C in the cytoplasm, resulting in increased nuclear translocation and activity of ZBTB7C. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl-cAMP, a cAMP analog, activates PKA which can enhance the activity of ZBTB7C by promoting its phosphorylation and subsequent activation of its target gene expression. | ||||||
Tanshinone IIA | 568-72-9 | sc-200932 sc-200932A | 5 mg 25 mg | $88.00 $316.00 | 22 | |
Tanshinone IIA has been shown to activate the ERK1/2 pathway. Active ERK1/2 can lead to downstream phosphorylation events that enhance ZBTB7C activity by promoting its stabilization and nuclear localization. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin is a JNK activator; JNK pathway activation leads to transcription factor activation which can include factors that increase ZBTB7C expression and function. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates SIRT1, leading to deacetylation of proteins that modulate transcription factors or cofactors involved in enhancing the activity of ZBTB7C by promoting its DNA binding capacity. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane activates Nrf2 signaling pathway. Active Nrf2 can increase the expression of genes with antioxidant response elements (AREs), which could include ZBTB7C or its coactivators. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin can inhibit NF-κB signaling, which may reduce the sequestration of coactivators required for ZBTB7C function, thereby indirectly increasing ZBTB7C activity. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid modulates RAR and RXR receptors that can form heterodimers with other transcription factors, potentially enhancing ZBTB7C transcriptional activity by increasing its access to target genes. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
TSA is a histone deacetylase inhibitor that can lead to a more relaxed chromatin structure, potentially increasing the accessibility of ZBTB7C to its target DNA regions and thus enhancing its activity. | ||||||