XPF Activators
The chemical class described as XPF Activators encompasses a diverse range of compounds that can indirectly influence the activity of XPF, a crucial protein in DNA repair mechanisms. This class includes various naturally occurring compounds and essential nutrients, each possessing unique properties that can modulate cellular pathways or environmental conditions conducive to the optimal functioning of XPF. These activators do not directly interact with XPF; instead, they exert their effects through the modulation of related pathways or by creating favorable cellular conditions.
Compounds like caffeine, curcumin, and resveratrol interact with cellular signaling pathways such as ATM/ATR kinase pathways or the NF-kB pathway, which are integral to the cellular response to DNA damage. By influencing these pathways, these compounds can indirectly enhance the recruitment and functional efficiency of XPF in DNA repair processes. Similarly, molecules like sulforaphane and epigallocatechin gallate (EGCG) activate transcription factors like Nrf2, influencing the antioxidant response and thus creating an environment that supports efficient DNA repair, indirectly affecting XPF activity. Additionally, nutrients like vitamin D3, zinc, selenium, and omega-3 fatty acids play significant roles in maintaining cellular health, particularly in the context of DNA repair and genomic stability. Vitamin D3 and retinoic acid modulate gene expression and cell cycle control, processes that are intimately linked with DNA repair mechanisms. Trace elements like zinc and selenium are critical for the activity of various DNA repair enzymes, thus indirectly supporting XPF function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine, a well-known stimulant, can influence ATM and ATR kinase pathways, which are crucial in DNA damage response. Activation of these pathways can indirectly enhance the recruitment and activity of XPF in DNA repair processes. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, a compound in turmeric, has been shown to modulate the NF-kB pathway and affect the expression of various genes related to DNA repair and cell cycle control. This modulation could indirectly activate XPF activity by altering cellular responses to DNA damage. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a polyphenol in red wine, can activate SIRT1, a deacetylase involved in DNA repair and genomic stability. By modulating SIRT1 activity, resveratrol may indirectly activate XPF function in DNA repair processes. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane, found in cruciferous vegetables, is known to activate Nrf2, a transcription factor that regulates antioxidant response. This activation can indirectly activate DNA repair mechanisms, potentially activating XPF activity. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, an isoflavone in soy, has been shown to affect DNA repair pathways. Its influence on these pathways could indirectly activate XPF activity by altering the cellular environment for DNA repair. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin, a flavonoid in many fruits and vegetables, can modulate various signaling pathways involved in cell stress responses. This modulation might indirectly activate XPF function in response to DNA damage. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG, the main catechin in green tea, has been observed to influence pathways related to oxidative stress and DNA repair. This influence might indirectly activate XPF activity. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, a derivative of vitamin A, can influence gene expression and cell differentiation pathways. Its role in these pathways could indirectly activate XPF activity by altering the cellular context for DNA repair. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Cholecalciferol can modulate gene expression and cell cycle control. This modulation could indirectly activate XPF activity in DNA repair processes. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc, an essential trace element, is crucial for the function of many DNA repair enzymes. Its presence can indirectly activate XPF function by ensuring optimal conditions for DNA repair enzyme activity. | ||||||