XAGE-1A Inhibitors
The chemical class of XAGE-1A inhibitors encompasses a diverse range of compounds that target various signaling pathways and cellular processes implicated in the regulation of XAGE-1A expression and activity. XAGE-1A is a cancer-testis antigen that plays a role in tumor progression and evasion of immune surveillance, making it an attractive target for cancer therapy.
One group of inhibitors includes those that target signaling pathways involved in cell survival, proliferation, and growth, such as the PI3K/AKT/mTOR pathway. Compounds like Wortmannin and Rapamycin inhibit PI3K and mTOR, respectively, leading to downstream effects on protein synthesis and cell growth, which can indirectly impact XAGE-1A expression by modulating cellular proliferation and survival pathways.
Another class of inhibitors includes those that target stress response pathways, such as the MAPK and ER stress pathways. Compounds like PD98059 and Thapsigargin inhibit MAPK and induce ER stress, respectively, leading to alterations in downstream transcriptional activities involved in cellular stress responses, which can indirectly influence XAGE-1A expression.
Furthermore, inhibitors targeting kinase enzymes, such as Src and ROCK, modulate signaling cascades involved in cellular proliferation and survival, potentially impacting XAGE-1A expression through downstream signaling events. Collectively, the chemical class of XAGE-1A inhibitors provides valuable tools for investigating the molecular mechanisms underlying XAGE-1A function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
5-Fluorouracil is an antimetabolite that inhibits thymidylate synthase, leading to decreased thymidine production and DNA synthesis, which can indirectly inhibit the expression of XAGE-1A, a gene involved in cellular proliferation. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
Bafilomycin A1 is a vacuolar ATPase inhibitor that prevents lysosomal acidification, leading to impaired autophagy and degradation processes, which can indirectly impact XAGE-1A expression by altering cellular homeostasis. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a phosphoinositide 3-kinase (PI3K) inhibitor that blocks PI3K-mediated signaling pathways involved in cell survival and proliferation, which can indirectly suppress XAGE-1A expression by inhibiting downstream signaling. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a mitogen-activated protein kinase kinase (MEK) inhibitor that blocks the MEK/ERK signaling pathway, which can indirectly regulate XAGE-1A expression by modulating downstream transcriptional activities. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is a mammalian target of rapamycin (mTOR) inhibitor that suppresses mTOR signaling, leading to inhibition of protein synthesis and cell growth, which can indirectly affect XAGE-1A expression by modulating cellular proliferation. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is a sarco/endoplasmic reticulum calcium ATPase (SERCA) inhibitor that disrupts calcium homeostasis and induces endoplasmic reticulum stress, which can indirectly influence XAGE-1A expression through cellular stress responses. | ||||||
AG-490 | 133550-30-8 | sc-202046C sc-202046A sc-202046B sc-202046 | 5 mg 50 mg 25 mg 10 mg | $82.00 $323.00 $219.00 $85.00 | 35 | |
AG-490 is a Janus kinase (JAK) inhibitor that blocks JAK/STAT signaling, which can indirectly regulate XAGE-1A expression by modulating downstream transcriptional activities involved in cell growth and survival. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
Dasatinib is a Src family kinase inhibitor that blocks Src-mediated signaling pathways, which can indirectly affect XAGE-1A expression by modulating downstream signaling events involved in cellular proliferation and survival. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 mitogen-activated protein kinase (MAPK) inhibitor that suppresses p38 MAPK signaling, which can indirectly regulate XAGE-1A expression by modulating downstream transcriptional activities involved in cellular stress responses. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $66.00 $153.00 | 16 | |
17-AAG is a heat shock protein 90 (HSP90) inhibitor that disrupts HSP90 chaperone function, leading to the degradation of client proteins involved in cell survival and proliferation, which can indirectly impact XAGE-1A expression. | ||||||