Wnt-3a Inhibitors
Wnt-3a inhibitors belong to a distinct chemical class that targets a specific signaling pathway within cells. The Wnt-3a signaling pathway plays a pivotal role in cellular processes like embryonic development, tissue homeostasis, and cell differentiation. Wnt-3a is a secreted glycoprotein that initiates this signaling cascade by binding to its receptor on the cell surface. Upon binding, a series of intracellular events are triggered, culminating in the activation of downstream genes responsible for regulating various cellular functions. Inhibitors of Wnt-3a specifically aim to modulate this signaling pathway by interfering with the interaction between Wnt-3a and its receptor, thereby downregulating the downstream effects of this pathway. The chemical structures of Wnt-3a inhibitors are diverse, reflecting the intricate nature of the Wnt signaling pathway. These inhibitors often possess functional groups that enable them to competitively bind to the Wnt-3a protein or its receptor, disrupting the binding of the native ligand and subsequently impeding the signaling cascade. Some Wnt-3a inhibitors act through small molecules, which are able to penetrate the cell membrane and target intracellular components of the pathway. Other inhibitors may involve larger molecules, such as antibodies, which can directly interact with the extracellular domain of Wnt-3a or its receptor. The design and development of these inhibitors require a deep understanding of the molecular interactions underlying the Wnt-3a signaling pathway, as well as the chemical properties necessary for effective inhibition.
In conclusion, Wnt-3a inhibitors represent a distinctive class of compounds designed to modulate the Wnt-3a signaling pathway. By interfering with the binding between Wnt-3a and its receptor, these inhibitors exert control over downstream cellular processes. The diverse chemical structures of these inhibitors highlight the complexity of the Wnt-3a signaling pathway and the multifaceted approaches employed in targeting this crucial cellular pathway.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
IWP-2 | 686770-61-6 | sc-252928 sc-252928A | 5 mg 25 mg | $94.00 $286.00 | 27 | |
IWP-2 inhibits Wnt protein palmitoylation, which is necessary for Wnt secretion and activity. This leads to decreased Wnt signaling through the interference with the Wnt-3a pathway and downstream target gene expression. | ||||||
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $35.00 $115.00 $515.00 | 26 | |
XAV939 promotes the degradation of β-catenin, a key component of the Wnt signaling pathway. It inhibits tankyrase enzymes, preventing the stabilization of Axin and thus promoting the degradation of β-catenin. This results in reduced Wnt-3a pathway activity and downstream effects. | ||||||
IWR-1-endo | 1127442-82-3 | sc-295215 sc-295215A | 5 mg 10 mg | $82.00 $132.00 | 19 | |
IWR-1 enhances the activity of Axin by disrupting the interaction between β-catenin and Axin, leading to increased degradation of β-catenin. This inhibits the Wnt-3a pathway by reducing β-catenin levels and subsequent target gene expression. | ||||||
LGK 974 | 1243244-14-5 | sc-489380 sc-489380A | 5 mg 50 mg | $352.00 $1270.00 | 2 | |
LGK974 is a porcupine (PORCN) inhibitor that blocks the secretion of Wnt proteins. It prevents the attachment of palmitate groups to Wnt molecules, rendering them inactive. This results in reduced Wnt-3a ligand availability and downstream signaling. | ||||||
PRI-724 | 1422253-38-0 | sc-507535 | 25 mg | $255.00 | ||
PRI-724 inhibits the interaction between β-catenin and its transcriptional co-activator CBP, thus preventing the transcriptional activation of Wnt target genes. This leads to the inhibition of Wnt-3a pathway-mediated gene expression and downstream effects. | ||||||
NSC 668036 | 144678-63-7 | sc-507412 | 5 mg | $175.00 | ||
NSC 668036 inhibits the Wnt/β-catenin signaling pathway by reducing the levels of disheveled (DVL) protein, which is essential for Wnt signal transduction. It disrupts DVL function, leading to decreased Wnt-3a pathway activity and downstream gene expression. | ||||||
β-Catenin/Tcf Inhibitor, FH535 | 108409-83-2 | sc-221398 sc-221398A | 10 mg 50 mg | $178.00 $367.00 | 7 | |
FH535 inhibits the Wnt/β-catenin pathway by targeting both Wnt and peroxisome proliferator-activated receptor δ (PPARδ) signaling. It reduces the interaction between β-catenin and TCF, leading to the inhibition of Wnt-3a pathway-mediated gene expression and downstream effects. | ||||||
1-[1,1′-Biphenyl]-4-yl-2-(2,3-dihydro-9H-imidazo[1,2-a]benzimidazol-9-yl)-ethanone Hydrobromide | 1219184-91-4 | sc-503576 | 10 mg | $360.00 | ||
1-[1,1'-Biphenyl]-4-yl-2-(2,3-dihydro-9H-imidazo[1,2-a]benzimidazol-9-yl)-ethanone Hydrobromide inhibits the interaction between β-catenin and TCF4, preventing the transcriptional activation of Wnt target genes. This leads to the inhibition of Wnt-3a pathway-mediated gene expression and downstream effects. | ||||||
PKF118-310 | 84-82-2 | sc-364590 sc-364590A | 5 mg 25 mg | $176.00 $638.00 | ||
PKF118-310 disrupts the interaction between β-catenin and TCF4, inhibiting the transcriptional activation of Wnt target genes. This results in the inhibition of Wnt-3a pathway-mediated gene expression and downstream effects. | ||||||
Cercosporin | 35082-49-6 | sc-255013 | 5 mg | $450.00 | 1 | |
Cercosporin inhibits the Wnt/β-catenin pathway by promoting the degradation of β-catenin. It induces the phosphorylation of β-catenin, marking it for ubiquitination and degradation. This leads to reduced Wnt-3a pathway activity and downstream target gene expression. | ||||||