WIBG Activators
WIBG activators encompass a range of chemical compounds that indirectly bolster the functional activity of WIBG, engaging with various signaling pathways to do so. Forskolin and Thapsigargin, through the elevation of cAMP and calcium levels respectively, activate downstream kinases like PKA that can phosphorylate proteins that interact with WIBG, thereby enhancing its role in RNA processing. Genistein, with its tyrosine kinase inhibitory activity, reduces competitive phosphorylation, potentially allowing WIBG to more effectively participate in mRNA export and stabilization. Similarly, the kinase inhibitors PMA and Epigallocatechin gallate modulate phosphorylation states of proteins within the mRNA processing pathways, which could lead to an increase in WIBG's functional activity related to pre-mRNA splicing and nuclear export.
Sphingosine-1-phosphate enhances WIBG's function in mRNA export by potentially influencing cytoskeletal arrangements that are integral to RNA transport processes. A23187, as a calcium ionophore, could indirectly promote WIBG's activities by facilitating the activation of calcium-dependent pathways essential for nuclear-cytoplasmic transport. Collectively, each of these activators orchestrates a cellular environment conducive to the heightened function of WIBG, ensuring greater efficiency in its critical roles in RNA metabolism without altering its expression levels directly.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin raises intracellular cAMP levels, which in turn activates PKA. PKA phosphorylates various substrates that can enhance the activity of WIBG by promoting its involvement in RNA processing and transport mechanisms. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein acts as a tyrosine kinase inhibitor, which can reduce competitive phosphorylation processes, thereby possibly allowing for enhanced activity of WIBG in its role of mRNA export and stabilization. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a PKC activator that can modulate signaling pathways affecting WIBG's role in pre-mRNA splicing by altering the phosphorylation state of splicing factors with which WIBG interacts. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
This compound acts as a kinase inhibitor, potentially enhancing WIBG's activity by reducing inhibitory phosphorylation of proteins that interact with WIBG in RNA transport. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
This lipid signaling molecule might enhance WIBG's function in mRNA export through S1P receptors, potentially influencing the cytoskeletal dynamics that WIBG could interact with during RNA transport. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin raises intracellular calcium levels, which could enhance WIBG's function indirectly by affecting calcium-dependent signaling pathways involved in nuclear-cytoplasmic transport. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a calcium ionophore that can raise intracellular calcium levels, potentially enhancing the activity of WIBG through the activation of calcium-dependent proteins that interact with WIBG during RNA processing. | ||||||