WBSCR16 Activators
WBSCR16 activators are a chemical class that influences the activity of the Williams-Beuren syndrome chromosome region 16 (WBSCR16) protein. The WBSCR16 protein is a part of a family of proteins that have a role in various cellular processes, although the full extent of its biological functions is not completely elucidated. These activators interact with the WBSCR16 protein, resulting in an increase in its activity within cells. This type of molecular interaction is typically characterized by binding to the protein at a specific site, which induces a conformational change in the protein's structure, thus modulating its function. The exact mechanism by which WBSCR16 activators exert their effect can vary, involving direct or indirect interactions with the protein or its associated molecular pathways.
The study of WBSCR16 activators is grounded in the domain of biochemistry and molecular biology, where the intricate details of protein function and regulation are key areas of interest. These activators are often identified through high-throughput screening methods, where large libraries of compounds are tested for their ability to modulate the activity of WBSCR16. Once identified, the activators can be subjected to further biochemical characterization to understand how they influence the protein's function. This might involve a range of experimental approaches, including but not limited to, X-ray crystallography, nuclear magnetic resonance, or cryo-electron microscopy to determine the structure of the protein-activator complex, as well as various in vitro assays to quantify the change in activity of the WBSCR16 protein. Understanding the molecular basis of how these activators function contributes to the broader knowledge of protein regulation in cellular environments.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, increasing intracellular cAMP levels. Elevated cAMP activates PKA, which can then phosphorylate WBSCR16, leading to its functional activation in relevant cellular processes. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels. The increase in calcium can activate calcium/calmodulin-dependent protein kinase (CaMK), which may phosphorylate WBSCR16 and enhance its activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC). PKC activation can lead to phosphorylation of WBSCR16, thereby enhancing its functional activity. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-Bromo-cAMP is a cell-permeable cAMP analog that activates PKA. PKA activation may result in the phosphorylation and subsequent activation of WBSCR16, similar to the effects of Forskolin. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 acts as a calcium ionophore, much like Ionomycin, leading to increased intracellular calcium and potential activation of CaMK-dependent pathways that could phosphorylate and activate WBSCR16. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases 1 and 2A, leading to increased phosphorylation levels of proteins. This inhibition may indirectly result in the enhanced phosphorylation and activation of WBSCR16. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a catechin known to inhibit certain protein kinases, potentially altering signaling pathways. This inhibition might lead to a compensatory response in cellular signaling that enhances the phosphorylation and activity of WBSCR16. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
S1P is a lipid signaling molecule that activates sphingosine-1-phosphate receptors, triggering intracellular signaling cascades. This activation could lead to downstream effects that enhance the functional activity of WBSCR16. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor. By inhibiting PI3K, it can reduce downstream Akt signaling, potentially causing an upregulation or increased activity of alternative pathways, including those that could activate WBSCR16. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK, which is part of the MAPK/ERK pathway. Inhibition of MEK can shift signaling dynamics, potentially leading to increased activation of other pathways that might enhance the activity of WBSCR16. | ||||||