Vmn2r36 Activators
Chemical activators of Vmn2r36 can induce conformational changes and functional activation through various intracellular signaling pathways. Calcium Chloride activates Vmn2r36 by increasing the extracellular calcium concentration, which allows calcium to enter the cell through calcium channels. Upon entry, calcium binds to Vmn2r36, initiating a conformational shift that activates the protein. Potassium Chloride operates in a similar manner by depolarizing the cell membrane, which causes voltage-sensitive calcium channels to open and the subsequent calcium influx to activate Vmn2r36. Histamine, through its receptors, and Glutamic Acid, via its own receptors, both increase the intracellular calcium concentration, directly activating Vmn2r36. Acetylcholine engages with muscarinic acetylcholine receptors, and Adenosine Triphosphate interacts with P2X purinergic receptors, both of which result in elevated intracellular calcium levels that activate Vmn2r36.
Additionally, Vmn2r36 activation is modulated by intracellular cyclic AMP (cAMP). Forskolin raises cAMP levels by activating adenylate cyclase, which then activates protein kinase A (PKA). PKA can phosphorylate Vmn2r36, leading to its activation. Isobutylmethylxanthine (IBMX) also increases cAMP by inhibiting phosphodiesterases, which in turn activates PKA and subsequently Vmn2r36. Serotonin and Dopamine activate Vmn2r36 via their respective receptors, which can lead to an increase in cAMP or calcium levels within the cell. These second messengers can directly activate Vmn2r36. Similarly, Norepinephrine binds to adrenergic receptors, increasing intracellular calcium or cAMP, both known activators of Vmn2r36. Lastly, Sodium Fluoride activates Vmn2r36 by inhibiting phosphodiesterases, leading to increased cAMP, PKA activation, and consequent phosphorylation and activation of Vmn2r36. Each of these chemicals, through distinct pathways, ensures the activation of Vmn2r36, contributing to the varied mechanisms by which Vmn2r36 can be regulated within the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Calcium chloride anhydrous | 10043-52-4 | sc-207392 sc-207392A | 100 g 500 g | $65.00 $262.00 | 1 | |
Calcium Chloride activates Vmn2r36 by increasing extracellular calcium concentration, which then enters the cell through calcium channels and directly activates Vmn2r36 by binding to necessary allosteric sites on the protein, leading to a change in its conformation and function. | ||||||
Potassium Chloride | 7447-40-7 | sc-203207 sc-203207A sc-203207B sc-203207C | 500 g 2 kg 5 kg 10 kg | $25.00 $56.00 $104.00 $183.00 | 5 | |
Potassium Chloride depolarizes the cell membrane potential, which can lead to the opening of voltage-sensitive calcium channels. The influx of calcium can then activate Vmn2r36 by inducing a conformational change necessary for its activation. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $92.00 $277.00 $969.00 | 7 | |
Histamine binds to its G-protein-coupled receptors on the cell surface, leading to an intracellular increase in calcium through the phospholipase C pathway. This rise in intracellular calcium concentration can directly activate Vmn2r36. | ||||||
L-Glutamic Acid | 56-86-0 | sc-394004 sc-394004A | 10 g 100 g | $291.00 $566.00 | ||
Glutamic Acid activates Vmn2r36 by binding to its glutamate receptors, which leads to an increase in intracellular calcium levels via NMDA or metabotropic receptors. This calcium signaling can directly activate Vmn2r36. | ||||||
Adenosine 5′-Triphosphate, disodium salt | 987-65-5 | sc-202040 sc-202040A | 1 g 5 g | $38.00 $74.00 | 9 | |
ATP activates Vmn2r36 through its action on P2X purinergic receptors, which leads to an influx of calcium. This increase in intracellular calcium directly activates Vmn2r36. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin raises intracellular cAMP levels by activating adenylate cyclase. Elevated cAMP activates protein kinase A (PKA), which can phosphorylate and activate Vmn2r36 or components of its signaling pathway. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX prevents the breakdown of cAMP by inhibiting phosphodiesterases, leading to increased levels of cAMP which in turn activate PKA. The activated PKA can phosphorylate and activate Vmn2r36. | ||||||
Serotonin hydrochloride | 153-98-0 | sc-201146 sc-201146A | 100 mg 1 g | $116.00 $183.00 | 15 | |
Serotonin activates Vmn2r36 through its receptors, which can lead to increased cAMP or calcium levels within the cell. Both cAMP and calcium are second messengers that can directly activate Vmn2r36. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine activates Vmn2r36 through dopamine receptors that modulate intracellular signaling via cAMP or calcium pathways. These signaling pathways can lead to the direct activation of Vmn2r36. | ||||||
L-Noradrenaline | 51-41-2 | sc-357366 sc-357366A | 1 g 5 g | $320.00 $475.00 | 3 | |
Norepinephrine activates Vmn2r36 by binding to adrenergic receptors, which increase intracellular calcium or cAMP. Both of these messengers are known to activate Vmn2r36 directly. | ||||||