Vmn2r21 Inhibitors
Vmn2r21 inhibitors pertain to a class of chemical agents designed to selectively inhibit the function of a specific receptor known as Vmn2r21. This receptor is part of a larger family of Vmn2r (Vomeronasal type-2 receptor) proteins, which are typically expressed in the vomeronasal organ (VNO) of certain mammals. The VNO is an olfactory chemoreceptor organ thought to be involved in the detection of pheromones, chemical compounds that carry information between individuals of the same species. Vmn2r21 receptors are G protein-coupled receptors (GPCRs), which are a broad and diverse group of membrane receptors that respond to a variety of external stimuli. These receptors have a distinct structure characterized by seven transmembrane domains, and they initiate a cellular response upon activation by their specific ligands.
The inhibitors of Vmn2r21 receptors have become a focal point of interest due to their selectivity and specificity towards these receptors. These inhibitors are typically small molecules that bind to the receptor, blocking the usual ligand interaction and subsequent signal transduction pathways within the cell. By preventing the normal functioning of Vmn2r21, these inhibitors can modulate the biological processes normally influenced by the receptor's activity. The development of these inhibitors requires a detailed understanding of the receptor's structure and the molecular dynamics of ligand-receptor interactions. Structure-activity relationship (SAR) studies are often employed to optimize the inhibitory compounds for higher potency and specificity. The inhibitors are usually identified through various techniques, including high-throughput screening, computational modeling, and iterative chemical synthesis, aimed at finding molecules that effectively interfere with the receptor's ability to function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of mitogen-activated protein kinase kinase (MEK), which is upstream of extracellular signal-regulated kinase (ERK) signaling. By inhibiting MEK and subsequently dampening ERK signaling, U0126 could indirectly influence the cellular environment of the olfactory sensory neurons where Vmn2r21 is expressed, potentially affecting its functional activity. | ||||||
Capsazepine | 138977-28-3 | sc-201098 sc-201098A | 5 mg 25 mg | $145.00 $450.00 | 11 | |
Capsazepine is a synthetic analog of capsaicin and a selective antagonist of the transient receptor potential vanilloid-1 (TRPV1). As Vmn2r21 is involved in chemosensory processes, TRPV1 antagonism could alter the sensory neuron's response to stimuli, which may indirectly decrease the functional activity of Vmn2r21 by modulating the neuronal signaling pathways in which it operates. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB-203580 is a pyridinyl imidazole derivative that functions as a potent and selective inhibitor of p38 MAP kinase. Inhibition of p38 MAP kinase could affect the phosphorylation state of proteins within olfactory sensory neurons and thus may indirectly modulate the signaling pathways that mediate the function of Vmn2r21, leading to reduced receptor activity. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is an inhibitor of Rho-associated protein kinase (ROCK), which is involved in regulating the shape and motility of cells via the actin cytoskeleton. Inhibition of ROCK may alter the intracellular signaling and cytoarchitecture of olfactory sensory neurons which express Vmn2r21, potentially affecting its localization and function within the cell membrane. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $89.00 $262.00 | 13 | |
ML-7 is a potent and selective inhibitor of myosin light chain kinase (MLCK). By inhibiting MLCK, ML-7 may disrupt the actin-myosin contractility within olfactory sensory neurons, which could indirectly influence Vmn2r21 function by altering cellular signaling and the mechanical forces that may be required for proper receptor activity. | ||||||
NF 449 | 389142-38-5 | sc-203159 | 10 mg | $308.00 | 5 | |
NF449 is a potent and selective antagonist of the P2X1 purinergic receptor. Purinergic signaling is known to modulate a variety of sensory neurons. By inhibiting P2X1 receptors, NF449 could indirectly diminish the activity of Vmn2r21 by altering the purinergic signaling pathways within the sensory neurons that may influence Vmn2r21 function. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $82.00 $192.00 $801.00 | ||
BAY K8644 is a dihydropyridine compound that acts as an L-type calcium channel agonist. While this chemical typically enhances calcium influx, its activity can lead to calcium channel desensitization or the activation of negative feedback mechanisms that ultimately reduce neurotransmitter release. This can indirectly inhibit Vmn2r21 function by affecting the signaling environment in the sensory neurons. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $58.00 $170.00 | 15 | |
Nifedipine is a selective L-type calcium channel blocker. | ||||||