Vmn1r60 Activators
Chemical compounds that act as Vomeronasal 1 receptor 60 (Vmn1r60) activators are predominantly involved in the binding and activation of this receptor, which is integral to the detection of pheromonal signals. Sulcatone, for example, is a ketone that can directly interact with Vmn1r60, leading to receptor activation through G protein-coupled signaling pathways. This action is characterized by the initiation of a signal transduction cascade that results in a cellular response specific to vomeronasal receptor activation. Similarly, 2-heptanone, another mammalian pheromone, binds to Vmn1r60, enhancing the receptor's signaling efficiency through G protein-coupled mechanisms. These interactions are crucial for the amplification of the chemical signals that Vmn1r60 is designed to detect.
Other activators, such as pregnenolone sulfate and icilin, do not directly bind to Vmn1r60 but instead modulate the receptor's activity by altering the cellular context or triggering downstream effects that potentiate Vmn1r60 signaling. Pregnenolone sulfate, for instance, changes the neuronal membrane composition, possibly increasing the sensitivity of Vmn1r60 to its ligands. Icilin, as an agonist of transient receptor potential channels, may induce cellular responses that synergistically enhance Vmn1r60's function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Pregnenolone sulfate sodium salt | 1852-38-6 | sc-301609 | 50 mg | $99.00 | 2 | |
Pregnenolone sulfate is a neurosteroid that acts on several receptors in the nervous system. It can potentiate Vmn1r60 activity indirectly by modulating the membrane potential and thereby altering the cellular environment in which Vmn1r60 operates, leading to enhanced receptor sensitivity. | ||||||
2-Heptanone | 110-43-0 | sc-238060 | 1 ml | $94.00 | ||
2-Heptanone is a ketone that can bind to and activate certain pheromone receptors. It enhances Vmn1r60 by direct binding, which can induce intracellular signaling through second messengers such as cAMP, leading to increased receptor function. | ||||||
Icilin | 36945-98-9 | sc-201557 sc-201557A | 10 mg 50 mg | $91.00 $257.00 | 9 | |
Icilin is a synthetic super-agonist of the transient receptor potential (TRP) channels. It can indirectly elevate Vmn1r60 activity by increasing intracellular calcium levels, which can amplify the signaling initiated by Vmn1r60 activation. | ||||||
Adenine, cell culture grade | 73-24-5 | sc-291834 sc-291834A sc-291834B | 5 g 25 g 100 g | $84.00 $210.00 $557.00 | 2 | |
Adenine, a purine nucleobase, can influence purinergic receptors and subsequent pathways. It can enhance Vmn1r60 by changing the purinergic signaling dynamics, indirectly affecting the receptor's activity through alterations in intracellular signaling networks. | ||||||
Piperine | 94-62-2 | sc-205809 sc-205809A | 5 g 25 g | $37.00 $146.00 | 3 | |
Piperine, an alkaloid from black pepper, can influence various receptors and enzymes. It enhances Vmn1r60 indirectly by affecting the endocannabinoid system, which in turn modulates G protein-coupled receptor (GPCR) activity, including that of Vmn1r60. | ||||||
(±)-beta-Citronellol | 106-22-9 | sc-294094 sc-294094A | 25 ml 500 ml | $32.00 $156.00 | ||
β-Citronellol is a terpene alcohol with odorant properties that can activate olfactory receptors. It can enhance Vmn1r60 activity by binding to the receptor, thereby triggering G protein signaling cascades that lead to increased receptor responsiveness. | ||||||
Indole | 120-72-9 | sc-257606 sc-257606A sc-257606B sc-257606C sc-257606D | 25 g 100 g 250 g 1 kg 5 kg | $30.00 $69.00 $124.00 $270.00 $1301.00 | 3 | |
Indole is an aromatic heterocyclic organic compound that can bind to olfactory receptors and may enhance Vmn1r60 by direct receptor interaction, promoting the activation of intracellular G protein-mediated pathways. | ||||||