Vmn1r224 Activators
Vomeronasal 1 receptor 224 activators encompass a range of compounds that indirectly influence the receptor's activity by modulating the intracellular signaling environment of GPCRs. Forskolin, by increasing cAMP, enhances PKA activity, which can then lead to the phosphorylation of proteins within the signaling pathways that Vmn1r224 might utilize, potentially resulting in an enhanced receptor response. Similarly, isoproterenol elevates cAMP levels, creating a signaling milieu that can amplify Vmn1r224 function through increased GPCR activity.
On the other hand, ionomycin and pilocarpine alter intracellular calcium levels, which can lead to the activation of PKC. PKC plays a pivotal role in the phosphorylation of proteins that are part of the GPCR signaling machinery, which in turn could enhance the signaling pathways involving Vmn1r224. Moreover, compounds such as carbachol and nicotine, by increasing PKC activity through cholinergic receptor activation, can further potentiate GPCR-mediated signaling pathways, which may include those related to Vmn1r224. Adenosine and bradykinin also contribute to this activation cascade by binding to their respective receptors and promoting the activities of cAMP and PKC, thereby fostering an environment conducive to the enhancement of Vmn1r224 signaling. Lastly, L-Arginine, through its role in the production of nitric oxide and subsequent activation of guanylyl cyclase, increases cGMP levels, which has the potential to modulate GPCR signaling pathways, including those associated with Vmn1r224, leading to an enhanced receptor activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP can enhance GPCR signaling by protein kinase A (PKA) activation, which could enhance Vmn1r224 signal transduction by phosphorylation of proteins in the pathway. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist which activates beta-adrenergic receptors, causing an increase in intracellular cAMP. This can indirectly enhance Vmn1r224 activity by promoting a signaling environment that favors GPCR function. | ||||||
Pilocarpine | 92-13-7 | sc-479256 | 100 mg | $250.00 | 1 | |
Pilocarpine is a muscarinic acetylcholine receptor agonist. Activation of the muscarinic pathway can modulate GPCR function through intracellular calcium mobilization and activation of protein kinase C (PKC), which can indirectly enhance Vmn1r224 signaling. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentrations. Elevated calcium can activate PKC, which in turn can phosphorylate downstream targets in GPCR pathways, potentially enhancing Vmn1r224 signaling. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-specific inhibitor of phosphodiesterases, which prevents the breakdown of cAMP and cGMP. Elevated levels of these cyclic nucleotides can enhance GPCR signaling, potentially increasing the activity of Vmn1r224. | ||||||
Carbachol | 51-83-2 | sc-202092 sc-202092A sc-202092C sc-202092D sc-202092B sc-202092E | 1 g 10 g 25 g 50 g 100 g 250 g | $120.00 $275.00 $380.00 $670.00 $1400.00 $3000.00 | 12 | |
Carbachol is a non-selective cholinergic agonist that can increase PKC activity through the muscarinic acetylcholine receptor pathway. Enhanced PKC activity can modulate GPCR signaling, potentially affecting Vmn1r224 function. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $92.00 $277.00 $969.00 | 7 | |
Histamine, through its action on histamine receptors, can modulate intracellular calcium levels and PKC activity. These changes can influence GPCR signaling cascades, potentially enhancing the signaling of Vmn1r224. | ||||||
Angiotensin II, Human | 4474-91-3 | sc-363643 sc-363643A sc-363643B sc-363643C | 1 mg 5 mg 25 mg 100 mg | $50.00 $75.00 $260.00 $505.00 | 3 | |
Angiotensin II, through its action on angiotensin receptors, which are GPCRs, can regulate downstream effectors like PKC and ultimately influence other GPCRs signaling, possibly including Vmn1r224. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $33.00 $47.00 $294.00 $561.00 $1020.00 $2550.00 $4590.00 | 1 | |
Adenosine binds to adenosine receptors, which are GPCRs, and can increase intracellular cAMP levels. This could create a favorable signaling environment for Vmn1r224 function. | ||||||
Bradykinin (1-3) | 23815-91-0 | sc-391193 sc-391193A sc-391193B | 5 mg 25 mg 100 mg | $151.00 $444.00 $1366.00 | ||
Bradykinin activates B2 receptors, which are GPCRs, leading to increased intracellular calcium and PKC activation. These signaling events can modulate GPCR function, potentially affecting Vmn1r224 signaling. | ||||||