Vmn1r155 Activators
Vomeronasal 1 receptor 155 activators encompass a diverse array of chemical compounds that engage with a variety of cellular mechanisms to enhance the functional activity of this G-protein-coupled receptor (GPCR). Sodium bicarbonate, by altering extracellular pH, can activate proton-sensitive receptors like Vmn1r155, while divalent cations supplied by calcium chloride and magnesium chloride are integral for GPCR activity, potentially augmenting Vmn1r155 signaling. Transition metals such as zinc, provided by zinc sulfate, can function as allosteric modulators to stabilize the active receptor conformation, enhancing ligand affinityand activation. Potassium chloride, by modulating the membrane potential, may also indirectly promote Vmn1r155 activity by fostering a cellular state conducive to receptor activation.
The modulation of intracellular signaling cascades is another avenue through which Vmn1r155 activators operate. Compounds like forskolin and isoproterenol elevate cAMP levels, which can activate PKA and may lead to the phosphorylation and activation of Vmn1r155, assuming it is coupled to a Gs protein. Sodium orthovanadate inhibits protein tyrosine phosphatases, potentially enhancing tyrosine phosphorylation pathways upon which Vmn1r155 activation might depend. Ionomycin, acting as a calcium ionophore, increases intracellular Ca2+ concentration and can activate calcium-sensitive pathways, potentially influencing Vmn1r155 activity. Similarly, L-Arginine can enhance the production of NO, which activates guanylyl cyclase, possibly affecting Vmn1r155 activation through cGMP-dependent signaling. NAD+ may modulate the receptor's activity indirectly through redox reactions, which are pivotal in GPCR signaling. Finally, piperine's role in inhibiting enzymes that regulate drug metabolism may enhance the bioavailability of Vmn1r155's endogenous ligands, thereby increasing receptor activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sodium bicarbonate | 144-55-8 | sc-203271 sc-203271A sc-203271B sc-203271C sc-203271D | 25 g 500 g 1 kg 5 kg 25 kg | $20.00 $28.00 $42.00 $82.00 $683.00 | 1 | |
Sodium bicarbonate, when introduced into cellular environments, can lead to changes in pH which may affect proton-sensitive G-protein-coupled receptors, such as vomeronasal 1 receptor 155 (Vmn1r155). Vmn1r155, being pH-sensitive, is likely to experience an enhancement in functional activity due to the localized alkalization induced by sodium bicarbonate, thus potentially increasing its signaling capacity. | ||||||
Calcium chloride anhydrous | 10043-52-4 | sc-207392 sc-207392A | 100 g 500 g | $65.00 $262.00 | 1 | |
Calcium chloride can increase intracellular Ca2+ levels, which is critical for the activation of many G-protein-coupled receptors (GPCRs). The influx of Ca2+ could amplify the functional activity of Vmn1r155, as the receptor may utilize Ca2+-dependent signaling pathways for its activation. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc ions have been shown to act as allosteric modulators of certain GPCRs. Zinc sulfate, supplying zinc ions, can enhance the functional activity of Vmn1r155 by stabilizing the receptor conformation that has a higher affinity for its ligands, thus facilitating its activation. | ||||||
Magnesium chloride | 7786-30-3 | sc-255260C sc-255260B sc-255260 sc-255260A | 10 g 25 g 100 g 500 g | $27.00 $34.00 $47.00 $123.00 | 2 | |
Similar to calcium, magnesium ions can also play a role in GPCR signaling. Magnesium chloride can provide Mg2+ ions that are essential for GPCR function, potentially enhancing the activity of Vmn1r155 through its role in maintaining receptor structure and function. | ||||||
Potassium Chloride | 7447-40-7 | sc-203207 sc-203207A sc-203207B sc-203207C | 500 g 2 kg 5 kg 10 kg | $25.00 $56.00 $104.00 $183.00 | 5 | |
By altering the membrane potential, potassium chloride can influence the activity of various receptors and channels. An increase in extracellular K+ concentration can lead to a more depolarized state, which may indirectly enhance the signaling of Vmn1r155 by promoting an environment that favors receptor activation. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $45.00 $56.00 $183.00 | 142 | |
Sodium orthovanadate is an inhibitor of protein tyrosine phosphatases. By preventing dephosphorylation, it can enhance tyrosine phosphorylation-dependent signaling pathways that may be involved in the activation of Vmn1r155. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP can activate protein kinase A (PKA), which may phosphorylate and enhance the functional activity of GPCRs, including Vmn1r155. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore which increases intracellular calcium concentration. Elevated Ca2+ levels can activate various secondary messenger pathways, potentially enhancing the functional activity of Vmn1r155 through Ca2+-sensitive signaling mechanisms. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist which can lead to the activation of Gs proteins and subsequent increase in cAMP levels. This upregulation of cAMP can indirectly enhance the functional activity of Vmn1r155 if the receptor is coupled to the Gs protein signaling pathway. | ||||||
L-Arginine | 74-79-3 | sc-391657B sc-391657 sc-391657A sc-391657C sc-391657D | 5 g 25 g 100 g 500 g 1 kg | $20.00 $30.00 $60.00 $215.00 $345.00 | 2 | |
L-Arginine is a precursor to nitric oxide (NO), a gaseous signaling molecule. NO can facilitate the activation of soluble guanylyl cyclase and the subsequent production of cGMP, which may influence the signaling cascade associated with Vmn1r155 activation. | ||||||