Vmn1r1 Activators
Vmn1r1, a vomeronasal 1 receptor, plays a crucial role in chemosensory perception within the vomeronasal organ. This receptor is implicated in detecting specific chemical cues involved in social and reproductive behaviors. Vmn1r1 activation is intricately regulated by various chemicals that either directly interact with the receptor or influence signaling pathways associated with its expression.
The receptor's function revolves around recognizing chemical cues, contributing to the regulation of social and reproductive behaviors in response to environmental stimuli. Vmn1r1 is expressed in sensory neurons of the vomeronasal organ, where its activation initiates cascades leading to neuronal responses associated with mating and social interactions. Activation mechanisms involve direct interactions with chemicals such as Retinoic Acid, Forskolin, and 9-cis-Retinoic Acid, modulating the retinoic acid and cAMP/PKA signaling pathways. Indirect activators like Sodium Butyrate and Lithium Chloride influence epigenetic modifications and Wnt/β-catenin pathway, respectively, promoting Vmn1r1 expression. This interconnected network of chemical modulators highlights the intricate regulation of Vmn1r1, underscoring its significance in chemosensory processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid, a vitamin A derivative, activates Vmn1r1 by modulating the retinoic acid signaling pathway. It enhances Vmn1r1 expression by directly binding to its promoter region, initiating a cascade that amplifies receptor sensitivity and promotes cellular response. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin stimulates adenylate cyclase, elevating cAMP levels and activating Vmn1r1 via the cAMP/PKA pathway. This amplifies the receptor's downstream signaling, up-regulating Vmn1r1 expression. Forskolin's role in cellular communication enhances Vmn1r1 activity by promoting the activation of related kinases and transcription factors. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates Vmn1r1 indirectly by modulating protein kinase C (PKC) signaling. It triggers a cascade leading to increased Vmn1r1 expression and enhanced receptor activity. The activation involves downstream effectors of PKC, influencing cellular processes that positively regulate Vmn1r1 function, thereby promoting its role in cellular responses. | ||||||
9-cis-Retinoic acid | 5300-03-8 | sc-205589 sc-205589B sc-205589C sc-205589D sc-205589A | 1 mg 25 mg 250 mg 500 mg 5 mg | $70.00 $416.00 $3060.00 $5610.00 $145.00 | 10 | |
9-cis-Retinoic Acid activates Vmn1r1 by engaging retinoic acid receptors (RARs). This interaction stimulates Vmn1r1 expression through direct binding to RAR response elements in the gene promoter. | ||||||
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $114.00 $175.00 $260.00 $362.00 $617.00 $1127.00 | ||
Adenosine 3',5'-cyclic monophosphate functions as a direct activator by modulating intracellular levels. It activates Vmn1r1 through the cAMP-dependent pathway, enhancing receptor expression and function. The increased cAMP acts as a secondary messenger, influencing downstream effectors and promoting cellular responses that contribute to the up-regulation of Vmn1r1, establishing a link between cyclic AMP signaling and Vmn1r1 activation. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 18 | |
Sodium Butyrate activates Vmn1r1 through epigenetic modulation. It functions as a histone deacetylase inhibitor, leading to increased histone acetylation at the Vmn1r1 promoter. This epigenetic modification promotes a permissive chromatin state, facilitating enhanced Vmn1r1 expression. Sodium Butyrate's role in chromatin remodeling establishes a mechanism for the indirect activation of Vmn1r1. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine, acting through adrenergic receptors, activates Vmn1r1 via the cAMP/PKA pathway. This stimulation enhances Vmn1r1 expression and cellular responses, linking adrenergic signaling to the up-regulation of Vmn1r1. The cascade initiated by epinephrine establishes a connection between sympathetic nervous system activation and the modulation of Vmn1r1 activity. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride indirectly activates Vmn1r1 by inhibiting GSK-3β. This inhibition leads to increased β-catenin stabilization, subsequently enhancing Vmn1r1 expression. The modulation of the Wnt/β-catenin pathway by lithium chloride establishes an indirect mechanism for Vmn1r1 activation, demonstrating the interconnectedness of signaling pathways in regulating receptor activity. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic acid sodium salt activates Vmn1r1 through histone deacetylase inhibition, promoting a chromatin state conducive to enhanced gene expression. This epigenetic modulation establishes a mechanism for sodium valproate in indirectly up-regulating Vmn1r1. The altered chromatin landscape facilitates increased accessibility to the Vmn1r1 promoter, contributing to the overall activation of the target receptor. | ||||||
Vitamin A | 68-26-8 | sc-280187 sc-280187A | 1 g 10 g | $377.00 $2602.00 | ||
Retinol, a precursor of retinoic acid, activates Vmn1r1 by serving as a substrate for retinoic acid synthesis. The conversion of retinol to retinoic acid influences Vmn1r1 expression, connecting retinol metabolism to the activation of the target receptor. This metabolic pathway establishes a link between cellular retinol levels and the regulation of Vmn1r1, highlighting the role of retinol in modulating receptor activity. | ||||||